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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sphk1tm1.1Cgh
targeted mutation 1, Shaun R Coughlin
MGI:3707992
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sphk1tm1.1Cgh/Sphk1tm1.1Cgh involves: 129S4/SvJae * C57BL/6 MGI:3708980
cn2
Sphk1tm1.1Cgh/Sphk1tm2Cgh
Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3708981


Genotype
MGI:3708980
hm1
Allelic
Composition
Sphk1tm1.1Cgh/Sphk1tm1.1Cgh
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1.1Cgh mutation (0 available); any Sphk1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• decrease in in vitro cardiomyocyte viability when exposed to hypoxia and glucose-deprivation for 4 hrs
• however, viability is no different from wild-type cardiomyocytes under normoxic culture conditions and pre-treatment with1uM of shingosine-1-phosphate improves viability




Genotype
MGI:3708981
cn2
Allelic
Composition
Sphk1tm1.1Cgh/Sphk1tm2Cgh
Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1.1Cgh mutation (0 available); any Sphk1 mutation (30 available)
Sphk1tm2Cgh mutation (2 available); any Sphk1 mutation (30 available)
Sphk2tm1.1Cgh mutation (1 available); any Sphk2 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• accumulation of mature T cells in the thymus without changes in other thymic subsets
• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
• accumulation of mature T cells in the thymus without changes in other thymic subsets
• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
• in the spleen and lymph
• in bone marrow and slightly in the lymph nodes
• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal
• undetectable levels of sphingosine-1-phosphate (S1P) in the plasma and lymph

hematopoietic system
• accumulation of mature T cells in the thymus without changes in other thymic subsets
• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
• accumulation of mature T cells in the thymus without changes in other thymic subsets
• decrease in the number of mature B cells in the bone marrow
• however, immature cell numbers are similar to controls
• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
• in the spleen and lymph
• in bone marrow and slightly in the lymph nodes
• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal

endocrine/exocrine glands
• accumulation of mature T cells in the thymus without changes in other thymic subsets

cardiovascular system
• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes
• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes and transfusion with wild-type platelets reduces vascular leakage of FITC-dextran





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory