All Phenotypes Tagln<tm2(cre)Yec> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tagln^tm2(cre)Yec
targeted mutation 2, Yuqing E Chen
MGI:3706313

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tagln^tm2(cre)Yec/Tagln^tm2(cre)Yec	involves: 129S6/SvEvTac * C57BL/6	MGI:3707234
cn2	Pdcd10^tm1Wami/Pdcd10^tm1Wami Tagln^tm2(cre)Yec/Tagln⁺	involves: 129 * 129S6/SvEvTac * C57BL/6	MGI:5002666
cn3	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297709
cn4	Apoe^tm1Unc/Apoe^tm1Unc Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Tagln^tm2(cre)Yec/Tagln⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:5781094
cn5	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺	involves: 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297710

Allelic Composition	Tagln^tm2(cre)Yec/Tagln^tm2(cre)Yec
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:119865 )

• homozygous and heterozygous mice are viable, fertile, and phenotypically normal; mice show cre expression in all vascular smooth muscle cells of all arteries and veins examined and in bladder and GI tract

Allelic Composition	Pdcd10^tm1Wami/Pdcd10^tm1Wami Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10^tm1Wami mutation (0 available); any Pdcd10 mutation (18 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:171969 )

N	• mice exhibit normal Mendelian ratio after weaning

cardiovascular system

cardiovascular system phenotype ( J:171969 )

N	• mice exhibit normal retinal vascular development

Allelic Composition	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2^tm1Bero mutation (1 available); any Msx2 mutation (23 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal artery morphology ( J:173525 )

• superficial temporal artery is more branched than in controls

abnormal carotid artery morphology ( J:173525 )

• at E11.5, carotid artery (CA) overbranching is observed

abnormal vertebral artery morphology ( J:173525 )

• vertebral artery (VA) caliber is increased relative to controls

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

intracranial aneurysm ( J:173525 )

• in the head, aneurysms are frequently observed

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

nervous system

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Ddit3^tm1.1Irt mutation (1 available); any Ddit3 mutation (20 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:233223 )

• aortic root shows a approximate 30% reduction in lesion area and necrotic area compared to Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes, indicating decreased atherosclerotic plaque progression

• smooth muscle cell content is lower in aortic arch lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• mice on a Western diet show a lower content of alpha-actin-positive vascular smooth muscle cells in the lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• lesions show decreased vascular smooth muscle cell proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:233223 )

N	• after 12 weeks of Western diet feeding, mice exhibit similar body weight, blood glucose, total plasma cholesterol, HDL cholesterol, plasma triglycerides, and blood pressure as Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes

Allelic Composition	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Rem mutation (1 available); any Msx1 mutation (18 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery section surface (increased vessel diameter) is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

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