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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-DBT)A1Geh
transgene insertion A1, Gregg E Homanics
MGI:3704903
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(Cebpb-tTA)5Bjd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI MGI:3704913
tg2
Tg(tetO-DBT)A1Geh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3704914


Genotype
MGI:3704913
cx1
Allelic
Composition
Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbttm1Geh mutation (1 available); any Dbt mutation (16 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-DBT)A1Geh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 4% of pups surviving to weaning have this genotype, compared to a theoretical survival rate or 14%, indicating partial rescue of the Dbttm1Geh phenotype
• transgenic mice survival is only ~16 weeks, when mice become moribund and are sacrificed

homeostasis/metabolism
• blood levels of alanine, glutamate, and glutamine are reduced compared to controls, but greater than in Dbttm1Geh homozygous mice
• BCAA/alanine (BCAA -branched-chain amino acids - leucine + isoleucine + valine) values are intermediate between controls and Dbt-null mice between 4-7 weeks of age
• levels of branched-chain keto acid dehydrogenase (BCKDH) activity are only 5-6% of controls levels, despite nearly equal protein levels, indicating suboptimal BCKDH activity of protein assembled with human E2

Mouse Models of Human Disease
OMIM ID Ref(s)
Maple Syrup Urine Disease; MSUD 248600 J:119973




Genotype
MGI:3704914
tg2
Allelic
Composition
Tg(tetO-DBT)A1Geh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO-DBT)A1Geh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• transgenic mice do not have any ascribed abnormal phenotype





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory