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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-DBT)A1Geh
transgene insertion A1, Gregg E Homanics
MGI:3704903
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(Cebpb-tTA)5Bjd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI MGI:3704913
tg2
Tg(tetO-DBT)A1Geh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3704914


Genotype
MGI:3704913
cx1
Allelic
Composition
Dbttm1Geh/Dbttm1Geh
Tg(tetO-DBT)A1Geh/0
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbttm1Geh mutation (1 available); any Dbt mutation (28 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-DBT)A1Geh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 4% of pups surviving to weaning have this genotype, compared to a theoretical survival rate or 14%, indicating partial rescue of the Dbttm1Geh phenotype
• transgenic mice survival is only ~16 weeks, when mice become moribund and are sacrificed

homeostasis/metabolism
• blood levels of alanine, glutamate, and glutamine are reduced compared to controls, but greater than in Dbttm1Geh homozygous mice
• BCAA/alanine (BCAA -branched-chain amino acids - leucine + isoleucine + valine) values are intermediate between controls and Dbt-null mice between 4-7 weeks of age
• levels of branched-chain keto acid dehydrogenase (BCKDH) activity are only 5-6% of controls levels, despite nearly equal protein levels, indicating suboptimal BCKDH activity of protein assembled with human E2

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maple syrup urine disease DOID:9269 OMIM:246900
OMIM:248600
OMIM:615135
J:119973




Genotype
MGI:3704914
tg2
Allelic
Composition
Tg(tetO-DBT)A1Geh/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO-DBT)A1Geh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• transgenic mice do not have any ascribed abnormal phenotype





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory