Phenotypes associated with this allele
Allelic Composition |
Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
|
|
Genetic Background |
either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man1a2tm1.1Ahe mutation
(1 available);
any
Man1a2 mutation
(32 available)
|
|
|
mortality/aging
|
• neonates die within several hours of birth
|
respiratory system
|
• within several hours of birth, display signs of respiratory distress
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man1a2tm1.1Ahe mutation
(1 available);
any
Man1a2 mutation
(32 available)
|
|
|
Thick interalveolar septae and alveolar hemorrhaging in E18.5 Man1a2tm1.1Ahe/Man1a2tm1.1Ahe lungs
mortality/aging
|
• neonates die within several hours of birth
|
respiratory system
|
• neonates exhibit alveolar hemorrhaging
• however, pulmonary capillary and blood vessel networks are normal
|
|
• lung development is delayed, with E18.5 and neonatal lungs at the canalicular stage of development instead of at the saccular stage, as in wild-type
|
|
• decrease in alveolar air space at E18.5
|
|
• small isolated atelectactic regions are occasionally seen in the lungs, however all lungs inflate sufficiently to briefly sustain life (4-10 hours)
|
|
• thickening of alveolar septae is seen at E18.5
|
|
• within several hours of birth, progressively display signs of respiratory distress
|
cardiovascular system
|
• neonates exhibit alveolar hemorrhaging
• however, pulmonary capillary and blood vessel networks are normal
|
homeostasis/metabolism