Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
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immune system
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N |
• mice show normal thymocyte development and splenic T cell numbers
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
Tcrbtm5Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
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immune system
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• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells
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hematopoietic system
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• the Tcrbtm1Slek allele is always rearranged in alphabeta T cells but the Tcrbtm5Slek allele is only rearranged in about half the T cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
Tcrbtm6Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
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immune system
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• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate
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hematopoietic system
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• rearrangement of the V gene segments to the D gene segment on the Tcrbtm6Slek allele occurs at much reduced rate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Slek mutation
(0 available);
any
Tcrb mutation
(94 available)
Tcrbtm1(Tcrb)Chb mutation
(0 available);
any
Tcrb mutation
(94 available)
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immune system
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• there is a decreased percentage of alpha-beta T cells expressing T Cell receptors (TCR) that are partially encoded Vbeta5 or Vbeta8 gene segments
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• in T cells, complete VbetaDJbeta exon rearrangement occurs more frequently (69%) on the Tcrbtm1(Tcrb)Chb allele than on the Tcrbtm1Slek allele (31%)
• sequencing of T cell hybridomas suggest there is both an increase in rearrangements on the Tcrbtm1(Tcrb)Chb allele and a preferential selection of thymocytes with in-frame VbetaDJbeta rearrangements on this allele
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• the frequency of DN3 thymocytes is slightly decreased while the frequency of DN4 thymocytes is slightly increased
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• frequency of CD8+ T cells in the spleen is slightly decreased
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• there is an increased frequency of single-positive thymocytes (both CD4+ and CD8+)
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hematopoietic system
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• there is a decreased percentage of alpha-beta T cells expressing T Cell receptors (TCR) that are partially encoded Vbeta5 or Vbeta8 gene segments
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• in T cells, complete VbetaDJbeta exon rearrangement occurs more frequently (69%) on the Tcrbtm1(Tcrb)Chb allele than on the Tcrbtm1Slek allele (31%)
• sequencing of T cell hybridomas suggest there is both an increase in rearrangements on the Tcrbtm1(Tcrb)Chb allele and a preferential selection of thymocytes with in-frame VbetaDJbeta rearrangements on this allele
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• the frequency of DN3 thymocytes is slightly decreased while the frequency of DN4 thymocytes is slightly increased
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• frequency of CD8+ T cells in the spleen is slightly decreased
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• there is an increased frequency of single-positive thymocytes (both CD4+ and CD8+)
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Analysis Tools
