About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spry4tm1.2Mrt
targeted mutation 1.2, Gail R Martin
MGI:3701941
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spry4tm1.2Mrt/Spry4tm1.2Mrt involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:3702558
cx2
Spry2tm1.1Mrt/Spry2+
Spry4tm1.2Mrt/Spry4tm1.2Mrt
involves: 129P2/OlaHsd MGI:6209558
cx3
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Spry4tm1.2Mrt/Spry4+
involves: 129P2/OlaHsd MGI:7309963


Genotype
MGI:3702558
hm1
Allelic
Composition
Spry4tm1.2Mrt/Spry4tm1.2Mrt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry4tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth

growth/size/body
• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth

skeleton
• diastema teeth are seen in 16% of mice, mostly unilaterally
• however, molar cusp pattern is essentially normal unlike in other mice with supernumerary teeth




Genotype
MGI:6209558
cx2
Allelic
Composition
Spry2tm1.1Mrt/Spry2+
Spry4tm1.2Mrt/Spry4tm1.2Mrt
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry4tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• display ciliopathy-like limb long bone phenotypes
• at E18.5
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
• axoneme elongation is seen in primary cilia of prenatal tibial chondrocytes

limbs/digits/tail
• defects in autopodium patterning
• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly
• at E18.5

cellular
• axoneme elongation is seen in prenatal tibial chondrocytes

neoplasm
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ciliopathy DOID:0060340 J:315670




Genotype
MGI:7309963
cx3
Allelic
Composition
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Spry4tm1.2Mrt/Spry4+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry4tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• display ciliopathy-like limb phenotypes
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

limbs/digits/tail
• defects in autopodium patterning
• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly

neoplasm
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate
• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ciliopathy DOID:0060340 J:315670





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory