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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gcktm3Mgn
targeted mutation 3, Mark A Magnuson
MGI:3701764
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gcktm3Mgn/Gcktm3Mgn 129S6/SvEvTac-Gcktm3Mgn MGI:3713301
ht2
Gcktm3Mgn/Gck+ 129S6/SvEvTac-Gcktm3Mgn MGI:3713300
ht3
Gcktm3Mgn/Gck+ B6.129S6-Gcktm3Mgn MGI:3713297


Genotype
MGI:3713301
hm1
Allelic
Composition
Gcktm3Mgn/Gcktm3Mgn
Genetic
Background
129S6/SvEvTac-Gcktm3Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm3Mgn mutation (2 available); any Gck mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• insulin/glucose ratio in fasted adults is significantly greater than in wild-type
• mice are more sensitive to glucose and islets secret insulin in response to 4.0 mM glucose
• basal glucose levels are lower than in heterozygotes (57.8 mg/dl vs 78.8 mg/dl)
• fasted 4-week old mice display mild hypoglycemia
• despite lower plasma glucose levels than wild-type, mice have similar plasma insulin levels relative to wild-type; insulin levels are lower than in heterozygous mice (0.32 ng/ml vs 0.45 ng/ml)
• glucokinase activity is reduced by 71.9% relative to wild-type

endocrine/exocrine glands
• mice are more sensitive to glucose and islets secret insulin in response to 4.0 mM glucose




Genotype
MGI:3713300
ht2
Allelic
Composition
Gcktm3Mgn/Gck+
Genetic
Background
129S6/SvEvTac-Gcktm3Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm3Mgn mutation (2 available); any Gck mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• ratio between plasma insulin and blood glucose level is significantly lower throughout the 120-minute period after glucose challenge
• insulin/glucose ratio in fasted, adults is significantly greater than in wild-type
• mice are more sensitive to glucose and islets secret insulin in response to 2.5 mM glucose
• fasted 4-week old mice display mild hypoglycemia
• glucokinase activity is reduced by 38% relative to wild-type

endocrine/exocrine glands
N
• islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet
• mice are more sensitive to glucose and islets secret insulin in response to 2.5 mM glucose




Genotype
MGI:3713297
ht3
Allelic
Composition
Gcktm3Mgn/Gck+
Genetic
Background
B6.129S6-Gcktm3Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm3Mgn mutation (2 available); any Gck mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hyperinsulinemic hypoglycemia DOID:13317 J:121910





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory