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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gcktm2Mgn
targeted mutation 2, Mark A Magnuson
MGI:3701697
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gcktm2Mgn/Gcktm2Mgn 129S6/SvEvTac-Gcktm2Mgn MGI:3713302
ht2
Gcktm2Mgn/Gck+ 129S6/SvEvTac-Gcktm2Mgn MGI:3713294
ht3
Gcktm2Mgn/Gck+ B6.129S6-Gcktm2Mgn MGI:3713296


Genotype
MGI:3713302
hm1
Allelic
Composition
Gcktm2Mgn/Gcktm2Mgn
Genetic
Background
129S6/SvEvTac-Gcktm2Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm2Mgn mutation (2 available); any Gck mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within a few days of birth from hyperglycemia

homeostasis/metabolism
• severe hyperglycemia is displayed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:121910




Genotype
MGI:3713294
ht2
Allelic
Composition
Gcktm2Mgn/Gck+
Genetic
Background
129S6/SvEvTac-Gcktm2Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm2Mgn mutation (2 available); any Gck mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• ratio between plasma insulin and blood glucose level is significantly higher throughout the 120-minute period after glucose challenge
• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose
• fasted 4-week old mice display mild hyperglycemia
• glucose regulation is impaired in mice
• glucokinase activity is reduced ~43% compared to wild-type mice

endocrine/exocrine glands
N
• islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet
• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:121910




Genotype
MGI:3713296
ht3
Allelic
Composition
Gcktm2Mgn/Gck+
Genetic
Background
B6.129S6-Gcktm2Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm2Mgn mutation (2 available); any Gck mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory