All Phenotypes Gck<tm2Mgn> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Gck^tm2Mgn/Gck^tm2Mgn
Genetic Background	129S6/SvEvTac-Gck^tm2Mgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm2Mgn mutation (2 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die within a few days of birth from hyperglycemia

homeostasis/metabolism

hyperglycemia ( J:121910 )

• severe hyperglycemia is displayed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:121910

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:121910 )

• ratio between plasma insulin and blood glucose level is significantly higher throughout the 120-minute period after glucose challenge

abnormal insulin secretion ( J:121910 )

• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

hyperglycemia ( J:121910 )

• fasted 4-week old mice display mild hyperglycemia

impaired glucose tolerance ( J:121910 )

• glucose regulation is impaired in mice

decreased glucokinase activity ( J:121910 )

• glucokinase activity is reduced ~43% compared to wild-type mice

endocrine/exocrine glands

N	• islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet

abnormal insulin secretion ( J:121910 )

• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:121910

Allelic Composition	Gck^tm2Mgn/Gck⁺
Genetic Background	B6.129S6-Gck^tm2Mgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm2Mgn mutation (2 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:121910 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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