Mouse Genome Informatics
hm1
    Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected

immune system
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)

hematopoietic system
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)