About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptgs2tm2(Ptgs1)Fun
targeted mutation 2, Colin D Funk
MGI:3701117
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3701210


Genotype
MGI:3701210
hm1
Allelic
Composition
Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2tm2(Ptgs1)Fun mutation (0 available); any Ptgs2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected (J:118171)
• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected (J:118171)

immune system
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2) (J:118171)
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2) (J:118171)

hematopoietic system
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2) (J:118171)
• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2) (J:118171)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory