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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tcra2D2,Tcrb2D2)1Kuch
transgene insertion 1, Vijay Kuchroo
MGI:3700794
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch MGI:4461061
cx2
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:4461060
cx3
Igh-Jtm1Aigl/Igh-J+
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4461059
cx4
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas MGI:3814894
cx5
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 MGI:5770303
cx6
Mogtm1Dpd/Mogtm1Dpd
Rag2tm1Cgn/Rag2tm1Cgn
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * C57BL/6 MGI:4461062
cx7
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * C57BL/6 MGI:4461058
cx8
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S5/SvEvBrd * C57BL/6 MGI:5770298
cx9
H2-T23tm2Cant/H2-T23tm2Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
involves: 129S6/SvEvTac MGI:3822040
cx10
H2-T23tm3Cant/H2-T23tm3Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
involves: 129S6/SvEvTac * C57BL/6 MGI:3822041
cx11
Tigittm1Sdl/Tigittm1Sdl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: C57BL/6 MGI:4939787
cx12
Cd5tm1.1Chra/Cd5tm1.1Chra
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: C57BL/6 * FVB/N MGI:5447726
tg13
Tg(Tcra2D2,Tcrb2D2)1Kuch/0 involves: 129P2/OlaHsd * C57BL/6 MGI:5447724
tg14
Tg(Tcra2D2,Tcrb2D2)1Kuch/0 involves: C57BL/6 MGI:3702265
tg15
Tg(Tcra2D2,Tcrb2D2)1Kuch/? involves: C57BL/6 * CD-1 MGI:3763122


Genotype
MGI:4461061
cx1
Allelic
Composition
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (47 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• between 15% and 20% of mice develop spontaneous EAE

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335




Genotype
MGI:4461060
cx2
Allelic
Composition
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Aigl mutation (0 available); any Igh-J mutation (11 available)
Mogtm1Dpd mutation (0 available); any Mog mutation (47 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• disease started between 7 and 10 weeks of age, with classical paralytic EAE signs

muscle
• in a minority of cases, with a spastic component

nervous system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues
• inflammatory infiltrates in the peripheral nervous system despite the absence of MOG within these tissues
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in the spinal cord
• within the spinal cord and optic nerve

vision/eye
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve

immune system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335




Genotype
MGI:4461059
cx3
Allelic
Composition
Igh-Jtm1Aigl/Igh-J+
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Aigl mutation (0 available); any Igh-J mutation (11 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• disease started between 7 and 10 weeks of age, with classical paralytic EAE signs

immune system
• fifty percent spontaneously develop opticospinal myelitis
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues

muscle
• in a minority of cases, with a spastic component

nervous system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues
• inflammatory infiltrates in the peripheral nervous system despite the absence of MOG within these tissues
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in the spinal cord
• within the spinal cord and optic nerve

vision/eye
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335




Genotype
MGI:3814894
cx4
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in conjunction with anti-CTLA-4 antibody treatment, mice exhibit reduced paralysis induced by experimental autoimmune encephalomyelitis (EAE) compared to wild type mice
• however, adoptive transfer of Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells increases paralysis induced by EAE despite treatment with anti-CTLA-4 antibodies compared to wild-type mice receiving Gt(ROSA)26Sortm2Awai Cd19tm1(cre)Cgn double heterozygous B cells




Genotype
MGI:5770303
cx5
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit accelerated onset and succumb to complete hindlimb paralysis faster than control mice




Genotype
MGI:4461062
cx6
Allelic
Composition
Mogtm1Dpd/Mogtm1Dpd
Rag2tm1Cgn/Rag2tm1Cgn
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1Dpd mutation (0 available); any Mog mutation (47 available)
Rag2tm1Cgn mutation (2 available); any Rag2 mutation (78 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• spontaneous EAE develops in two out of six mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335




Genotype
MGI:4461058
cx7
Allelic
Composition
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1Dpd mutation (0 available); any Mog mutation (47 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• disease started between 7 and 10 weeks of age, with classical paralytic EAE signs

immune system
• between 15% and 20% of mice develop spontaneous EAE
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues

muscle
• in a minority of cases, with a spastic component

nervous system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues
• inflammatory infiltrates in the peripheral nervous system despite the absence of MOG within these tissues
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in the spinal cord
• within the spinal cord and optic nerve

vision/eye
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:151335




Genotype
MGI:5770298
cx8
Allelic
Composition
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit accelerated onset compared with control mice




Genotype
MGI:3822040
cx9
Allelic
Composition
H2-T23tm2Cant/H2-T23tm2Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm2Cant mutation (0 available); any H2-T23 mutation (19 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro
• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell
• transfer of CD4 T cells into Rag2-/- Prf1-/- hosts initiates a progressive and lethal form of EAE that results in death from fulminant disease within 14?16 days after transfer
• co-transfer of CD8 T regulatory cells with mutant CD4 T cells prevents disease where as co-transfer of CD8 T regulatory cells with transgenic CD4 T cells not carrying the H2-T23 mutation fails to prevent disease

hematopoietic system
• CD4 T cells are highly susceptible to dose-dependent suppression by CD8 T regulatory cells in vitro
• this suppression is dependent on Fas ligand being expressed by the CD8 T regulatory cell




Genotype
MGI:3822041
cx10
Allelic
Composition
H2-T23tm3Cant/H2-T23tm3Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm3Cant mutation (0 available); any H2-T23 mutation (19 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4 T cells are fully resistant to suppression by CD8 T regulatory cells in vitro as measured by proliferation and IL-2 secretion

hematopoietic system
• CD4 T cells are fully resistant to suppression by CD8 T regulatory cells in vitro as measured by proliferation and IL-2 secretion




Genotype
MGI:4939787
cx11
Allelic
Composition
Tigittm1Sdl/Tigittm1Sdl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Tigittm1Sdl mutation (0 available); any Tigit mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:5447726
cx12
Allelic
Composition
Cd5tm1.1Chra/Cd5tm1.1Chra
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd5tm1.1Chra mutation (0 available); any Cd5 mutation (11 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• under nonpolarizing conditions
• in CD4+ T cells stimulated with anti-CD3
• in CD4+ T cells under nonpolarizing conditions
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• IL2 levels from CD4+ T cells stimulated with MOG35-55 do not persist as long as in cells from wild-type mice
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

hematopoietic system
• under nonpolarizing conditions
• in CD4+ T cells stimulated with anti-CD3




Genotype
MGI:5447724
tg13
Allelic
Composition
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• under Th17 polarizing conditions
• under nonpolarizing conditions, Th1 cells are reduced 50% compared to in wild-type but are 3-fold higher than in Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in T cells cultures stimulated with MOG35-55
• 50% under Th17 polarizing conditions compared with wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in T cells cultures stimulated with MOG35-55
• under Th2 polarizing conditions compared with wild-type controls and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• of CD4+ T cells stimulated with anti-CD3
• in CD4+ T cells stimulated with MOG35-55, rested then restimulated with MOG35-55 compared with cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in CD4+ T cells under nonpolarizing conditions
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• IL10 levels in T cells stimulated with MOG35-55 rise and contract unlike in cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice where levels continue to rise
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• IL2 levels from T cells stimulated with MOG35-55 do not increase beyond day 1unlike in cells from wild-type control
• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

cellular
• under Th17 polarizing conditions

hematopoietic system
• under Th17 polarizing conditions
• under nonpolarizing conditions, Th1 cells are reduced 50% compared to in wild-type but are 3-fold higher than in Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in T cells cultures stimulated with MOG35-55
• 50% under Th17 polarizing conditions compared with wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• in T cells cultures stimulated with MOG35-55
• under Th2 polarizing conditions compared with wild-type controls and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice
• of CD4+ T cells stimulated with anti-CD3
• in CD4+ T cells stimulated with MOG35-55, rested then restimulated with MOG35-55 compared with cells from wild-type control and Cd5tm1Cgn/Cd5tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice




Genotype
MGI:3702265
tg14
Allelic
Composition
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 40% of transgenic mice succumb to EAE compared to no non-transgenic littermates

nervous system
• 7/15 mice without EAE show typical myelinating/demyelinating lesions of optic neuritis
• mice with EAE show typical myelinating/demyelinating lesions of optic neuritis
• 55 and 78% of transgenic mice immunized with 100 and 10 ug of MOG 35-55 without PT, respectively, develop optic nerve lesions
• mice with or without EAE that display optic neuritis have myelinating/demyelinating lesions consisting of subpial and endoneurial mononuclear cell infiltrates with demyelination indicated by presence of foamy macrophages
• mice with optic neuritis have varying degrees of axonal injury and loss
• CNS tissues show myelin loss

vision/eye
• mice without EAE develop superficial inflammation around the eyelids; this is unilateral and not observed in wild-type littermates during up to 1 year observation
• superficial eye lesions in mice without EAE are often associated with progressive atrophy of the eye
• 67% of mutants show these eye lesions compared to no wild-type
• mice without EAE show eyelid inflammation and eyelid swelling; this is unilateral and not observed in wild-type littermates during up to 1 year observation
• mice with or without EAE that display optic neuritis have myelinating/demyelinating lesions consisting of subpial and endoneurial mononuclear cell infiltrates with demyelination indicated by presence of foamy macrophages

immune system
• CD4/CD8 single positive ratio in thymus of transgenic mice is biased toward CD4+ compartment
• analysis shows a skewing toward CD4+ T cells in spleens as well
• spleen cells from naive mice produce high levels of IFN gamma in response to MOG 35-55
• 4% (3/72) of mice develop spontaneous EAE, indicated initially by a limp tail, followed by hindlimb paralysis between 2.5 and 5 months of age
• 55 and 78% of mice immunized with 100 and 10 ug of MOG 35-55 without PT, respectively, develop optic nerve lesions
• mice with disease have typical myelinating/demyelinating lesions
• transgenic mice immunized with MOG 35-55 + pertussis toxin (PT) develop more severe EAE than non-transgenic littermates, with earlier onset and greater clinical scores; 50% of mice develop associated optic neuritis also
• injection of PT alone induces clinical EAE in 39% and histological EAE in 56% of transgenics compared to no non-transgenic mice; 80% of mice develop associated optic neuritis also
• 7/15 mice without EAE show typical myelinating/demyelinating lesions of optic neuritis
• mice with EAE show typical myelinating/demyelinating lesions of optic neuritis
• 55 and 78% of transgenic mice immunized with 100 and 10 ug of MOG 35-55 without PT, respectively, develop optic nerve lesions
• mice without EAE develop superficial inflammation around the eyelids; this is unilateral and not observed in wild-type littermates during up to 1 year observation

hematopoietic system
• CD4/CD8 single positive ratio in thymus of transgenic mice is biased toward CD4+ compartment
• analysis shows a skewing toward CD4+ T cells in spleens as well

cellular
• spleen cells from naive mice show increased proliferative response to myelin oligodendrocyte protein peptide 35-55 (MOG 35-55) compared to wild-type mice

homeostasis/metabolism
• EAE-affected mice showed edema in the brain and spinal cord
• mice without EAE show eyelid inflammation and eyelid swelling; this is unilateral and not observed in wild-type littermates during up to 1 year observation




Genotype
MGI:3763122
tg15
Allelic
Composition
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
Genetic
Background
involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells incubated with LPS-stimulated CD11c+ dendritic cells with IL-23 in the presence of MOG peptide and neutralizing antibodies against IFN-gamma and IL-4 plus either IL-25 or IL-13 antibodies produce less IL-17 than with both IL-25 and IL-13 antibodies or without either





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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory