Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1tm1Rexu mutation
(0 available);
any
Syne1 mutation
(202 available)
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muscle
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• nuclei are disorganized in muscle fibers of mutants; nuclei cluster abnormally, with >99% of muscle fibers have nuclear clusters
• numbers of synaptic nuclei is reduced, but numbers of nuclei peripheral to synapse are increased compared to controls
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nervous system
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• no nuclei are observed under the neuromuscular junctions (NMJ) in mutants, compared to 4-5 seen in controls; synapse-associated nuclei are dramatically reduced in number compared to controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1tm1Rexu mutation
(0 available);
any
Syne1 mutation
(202 available)
Syne2tm1Rexu mutation
(0 available);
any
Syne2 mutation
(297 available)
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mortality/aging
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• double homozygotes are born, but die within 20 minutes
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respiratory system
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• mice fail to move their ribcages, but can move limbs in response to stimuli
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• mice are unable to breathe
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nervous system
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• phrenic nerve-diaphragm neuromuscular synapses have broader endplates than controls
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• phrenic nerve has significantly longer branches than controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syne1tm1Rexu mutation
(0 available);
any
Syne1 mutation
(202 available)
Syne2tm1Rexu mutation
(0 available);
any
Syne2 mutation
(297 available)
|
|
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nervous system
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• phrenic nerve-diaphragm neuromuscular synapses have broader endplates than controls
|
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• phrenic nerve has significantly longer branches than controls
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