Phenotypes associated with this allele

• Allele Symbol: Adgre5^tm1Kake
• Allele Name: targeted mutation 1, Kathleen Kelly
• Allele ID: MGI:3700734
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgre5^tm1Kake/Adgre5^tm1Kake	B6.129S6-Adgre5^tm1Kake	MGI:3700929

Genotype
MGI:3700929

hm1

• Allelic Composition: Adgre5^tm1Kake/Adgre5^tm1Kake
• Genetic Background: B6.129S6-Adgre5^tm1Kake

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:118705 )

• mice are resistant to mortality from acute L. monocytogenes infection (40% mortality) compared to wild-type (80% mortality)

• mutants develop long-term immunity

immune system

immune system phenotype ( J:118705 )

N • mutants show similar expression and production of monocyte-, natural killer- and T-cell derived inflammatory cytokines and chemokines, as well as granulopoietic cyto- and chemokines compared to wild-type

N • granulocytes from mutants show similar migratory properties to wild-type in vivo and in vitro

increased granulocyte number ( J:118705 )

• adult mice show a mild peripheral granulocytosis upon necropsy

• in peripheral blood, mutants have 2-fold more basal granulocytes than wild-type before infection; at 1 day post infection, there are ~50% more granulocytes than in wild-type

decreased susceptibility to bacterial infection ( J:118705 )

• at 8 hours after infection with L. monocytogenes, less bacteria are recovered from spleens and livers of mutants compared to wild-type

• at 72 hours, mutants have 3-fold fewer microabscesses than wild-type

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:118705 )

• mice are resistant to mortality from acute L. monocytogenes infection (40% mortality) compared to wild-type (80% mortality)

• mutants develop long-term immunity

hematopoietic system

increased granulocyte number ( J:118705 )

• adult mice show a mild peripheral granulocytosis upon necropsy

• in peripheral blood, mutants have 2-fold more basal granulocytes than wild-type before infection; at 1 day post infection, there are ~50% more granulocytes than in wild-type