Phenotypes associated with this allele

• Allele Symbol: Ptpn13^tm1Gru
• Allele Name: targeted mutation 1, Michael J Grusby
• Allele ID: MGI:3700029
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn13^tm1Gru/Ptpn13^tm1Gru	involves: C57BL/6	MGI:3700538

Genotype
MGI:3700538

hm1

• Allelic Composition: Ptpn13^tm1Gru/Ptpn13^tm1Gru
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:118426 )

• in response to cytokine stimulation, CD4+ T cells show increased and prolonged STAT4 phosphorylation

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:118426 )

• Th1 and Th2 differentiation is increased in mutant CD4+ T cells compared to wild-type

abnormal cytokine secretion ( J:118426 )

• interferon gamma (Ifng)and Il-4 production is increased in CD4+ T cells as result of prolonged STAT4 phophorylation

decreased susceptibility to bacterial infection ( J:118426 )

• wild-type mice have 35-fold more living K. pneumoniae in the lungs 2 days after infection than mutant mice, likely due to increased cytokine elaboration by Ptpn13-deficient CD4+ T cells

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:118426 )

• Th1 and Th2 differentiation is increased in mutant CD4+ T cells compared to wild-type