|
Allele Symbol Allele Name Allele ID |
Kcne2tm1Gwab targeted mutation 1, Geoffrey W Abbott MGI:3699589 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Kcne2tm1Gwab/Kcne2tm1Gwab mice have enlarged stomachs
|
• marked hyperplasia of the glandular stomach
|
|
• intracellular canaliculi are much larger and displace the mitochondria to the cell periphery
• however, no obvious abnormalities in the chief cells are detected
|
|
• gastric glandular hyperplasia with lengthening of the fundus and neck portions of the stomach
• hyperplastic glands are primarily lined with tall, columnar cells with excess cytoplasm that appear to be mucous neck and/or chief cells
• hyperplasia appears to only affect the non-acid secretory cell types
|
|
• mild to moderate numbers of neutrophils are seen scattered through the lamina propria basally, submucosa, and muscularis
|
|
• at 12 - 15 weeks of age about a 4-fold increase in stomach mass is seen
• enlarged stomachs have prominent rugal folds and marked hyperplasia of the glandular stomach
|
|
• mice display achlorhydria
|
|
• acid loaded parietal cells have a much lower rate of proton secretion, about 0.01 pH units/minute compared to about 0.1 units/minute in wild-type controls
|
|
• mean luminal pH in the stomach under basal conditions is 6.5 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls
• luminal pH is not significantly altered by histamine, unlike in wild-type controls
|
|
• marked elevation in serum gastrin levels
|
|
• intracellular canaliculi are much larger and displace the mitochondria to the cell periphery
• however, no obvious abnormalities in the chief cells are detected
|
|
• gastric glandular hyperplasia with lengthening of the fundus and neck portions of the stomach
• hyperplastic glands are primarily lined with tall, columnar cells with excess cytoplasm that appear to be mucous neck and/or chief cells
• hyperplasia appears to only affect the non-acid secretory cell types
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• parietal and chief cell morphology appears similar to wild-type controls despite the decrease in stomach pH
|
|
• acid loaded parietal cells have a lower rate of proton secretion, about 0.05 pH units/minute compared to about 0.1 units/minute in wild-type controls
|
|
• mice display hypochlohydria
|
|
• mean luminal pH in the stomach under basal conditions is 4.6 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls
• however, luminal pH is significantly altered by histamine similar to wild-type controls and unlike homozygous mice
|
| N |
• serum gastrin levels are similar to wild-type controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• stomachs are 2-fold heavier than in wild-type mice
|
|
• compared with wild-type mice and Kcne2tm1Gwab homozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools