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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stoml3tm1Glwn
targeted mutation 1, Gary R Lewin
MGI:3699212
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Stoml3tm1Glwn/Stoml3tm1Glwn involves: 129P2/OlaHsd * C57BL/6N MGI:3700232


Genotype
MGI:3700232
hm1
Allelic
Composition
Stoml3tm1Glwn/Stoml3tm1Glwn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stoml3tm1Glwn mutation (0 available); any Stoml3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants respond significantly only to the coarsest grid in a test for responses to a grating cue in the dark, whereas controls show a significant response to all grids tested
• after chronic constriction injury (CCI) of the sciatic nerve, mutants do not show any hyperalgesia (threshold decreases to ~1 gram) until the third day after injury, compared to wild-type mice which developed allodynia within a few days, with mechanical thresholds decreasing from 3 grams to less than 0.25 grams

nervous system
• mutants show an increase in mechanically insensitive A fibers (Abeta and Agamma) compared to wild-type
• percentage of insensitive C fibers is not significantly changed
• abount 36% of isolated sensory neurons from mutant mice show no current response to mechanical stimulation of the neurites; proportion of cells displaying slowly or rapidly adapting mechanically elevated currents is slightly reduced compared to wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory