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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapkapk5tm1Pqs
targeted mutation 1, Peiqing Sun
MGI:3698841
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3723513
ht2
Mapkapk5tm1Pqs/Mapkapk5+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3723514
cx3
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs
Tg(SV40-NRAS*G12D)1Sco/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3757991
cx4
Mapkapk5tm1Pqs/Mapkapk5+
Tg(SV40-NRAS*G12D)1Sco/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3757992


Genotype
MGI:3723513
hm1
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 1 of 13 mice died of unidentifiable causes following treatment with DMBA

neoplasm
• 7 of 13 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice
• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment
• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10 mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection
• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium
• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors
• however, untreated mice are healthy and tumor-free for at least 2 years

cellular
• mouse skin fibroblast cells derived from mice express less ras-induced senescence markers than wild-type DMBA-induced tumors

integument
• 7 of 13 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice
• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment
• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10 mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection
• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium
• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors
• however, untreated mice are healthy and tumor-free for at least 2 years




Genotype
MGI:3723514
ht2
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5tm1Pqs homozygotes
• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment
• only one papilloma progressed to malignant carcinoma 5 months after detection
• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection
• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium
• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors
• however, untreated mice are healthy and tumor-free for at least 2 years

cellular
• mouse skin fibroblast cells derived from mice express less ras-induced senescence markers than wild-type DMBA-induced tumors

integument
• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5tm1Pqs homozygotes
• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment
• only one papilloma progressed to malignant carcinoma 5 months after detection
• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection
• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium
• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors
• however, untreated mice are healthy and tumor-free for at least 2 years




Genotype
MGI:3757991
cx3
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5tm1Pqs
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lymphomagenesis is enhanced in the few surviving mice relative to in Tg(SV40-NRAS*G12D)1Sco mice




Genotype
MGI:3757992
cx4
Allelic
Composition
Mapkapk5tm1Pqs/Mapkapk5+
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5tm1Pqs mutation (0 available); any Mapkapk5 mutation (30 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lymphomagenesis is enhanced relative to in Tg(SV40-NRAS*G12D)1Sco mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory