Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation
(0 available);
any
Suds3 mutation
(22 available)
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mortality/aging
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• homozygous embryos are not produced at E6.5 or later
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Allelic Composition |
Suds3tm1.1Rdp/Suds3+
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Genetic Background |
involves: C57BL/6 * FVB |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation
(0 available);
any
Suds3 mutation
(22 available)
|
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normal phenotype
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• heterozygotes have normal lifespans, normal organs, age-related physiology and tissue changes, and normal cancer incidence
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation
(0 available);
any
Suds3 mutation
(22 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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cellular
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• tumor cells in primary cultures are typically aneuploid with chromosome counts of 30 to >100; tumors from controls are usually euploid
• tumor metaphases posess multi-radial chromosomes and sometimes more than 3 chromosomes are associated through their centromeric regions
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neoplasm
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• compared to Suds3-sufficient Trp53-null mice, mice show increased tumor multiplicity per mouse (2.45 vs 1.2 macroscopic tumors)
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• compared to Suds3-sufficient Trp53-null mice, mice show accelerated tumor onset (latency of 12.3 vs 13.9 weeks)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation
(0 available);
any
Suds3 mutation
(22 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
|
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neoplasm
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• mice show a suppression of the cancer phenotype compared to Sds-haploinsufficinet, Trp53-null mice
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