About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Suds3tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3698418
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Suds3tm1.1Rdp/Suds3tm1.1Rdp involves: 129S6/SvEvTac MGI:3698874
ht2
Suds3tm1.1Rdp/Suds3+ involves: C57BL/6 * FVB MGI:3698866
cx3
Suds3tm1.1Rdp/Suds3+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6 * FVB MGI:3698863
cx4
Suds3tm1.1Rdp/Suds3+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * C57BL/6 * FVB MGI:3698864


Genotype
MGI:3698874
hm1
Allelic
Composition
Suds3tm1.1Rdp/Suds3tm1.1Rdp
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation (0 available); any Suds3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos are not produced at E6.5 or later




Genotype
MGI:3698866
ht2
Allelic
Composition
Suds3tm1.1Rdp/Suds3+
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation (0 available); any Suds3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• heterozygotes have normal lifespans, normal organs, age-related physiology and tissue changes, and normal cancer incidence




Genotype
MGI:3698863
cx3
Allelic
Composition
Suds3tm1.1Rdp/Suds3+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation (0 available); any Suds3 mutation (22 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• tumor cells in primary cultures are typically aneuploid with chromosome counts of 30 to >100; tumors from controls are usually euploid
• tumor metaphases posess multi-radial chromosomes and sometimes more than 3 chromosomes are associated through their centromeric regions

neoplasm
• compared to Suds3-sufficient Trp53-null mice, mice show increased tumor multiplicity per mouse (2.45 vs 1.2 macroscopic tumors)
• compared to Suds3-sufficient Trp53-null mice, mice show accelerated tumor onset (latency of 12.3 vs 13.9 weeks)




Genotype
MGI:3698864
cx4
Allelic
Composition
Suds3tm1.1Rdp/Suds3+
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suds3tm1.1Rdp mutation (0 available); any Suds3 mutation (22 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice show a suppression of the cancer phenotype compared to Sds-haploinsufficinet, Trp53-null mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory