Phenotypes associated with this allele

• Allele Symbol: Ybx1^tm1Tuch
• Allele Name: targeted mutation 1, Takeshi Uchiumi
• Allele ID: MGI:3698273
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ybx1^tm1Tuch/Ybx1^tm1Tuch	involves: 129S/SvEv * C57BL/6	MGI:3698882

Genotype
MGI:3698882

hm1

• Allelic Composition: Ybx1^tm1Tuch/Ybx1^tm1Tuch
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exencephaly in Ybx1^tm1Tuch/Ybx1^tm1Tuch embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:117725 )

• embryos die between E14.5 and E18.5; most homozygous embryos have been resorbed by E17.5

embryo

embryonic growth retardation ( J:117725 )

• growth is retarded as early as E10.5; early embryos are smaller than controls, but no organ or limb gross abnormalities are observed

incomplete rostral neuropore closure ( J:117725 )

• hindbrain region of embryos show incomplete anterior neural tube closure between E115-13.5

growth/size/body

embryonic growth retardation ( J:117725 )

• growth is retarded as early as E10.5; early embryos are smaller than controls, but no organ or limb gross abnormalities are observed

cellular

abnormal cell morphology ( J:117725 )

• mutant MEFs are round and have lower cell densities compared to wild-type which are elongated

decreased fibroblast proliferation ( J:117725 )

• in culture, MEFs show reduced proliferation and numbers after 4 to 5 passages

craniofacial

abnormal mandible morphology ( J:117725 )

• mutants achieving skull closure demonstrated retarded mandible development

abnormal maxilla morphology ( J:117725 )

• mutants achieving skull closure demonstrated retarded maxilla development

hematopoietic system

abnormal definitive hematopoiesis ( J:117725 )

• defects in erythropoiesis are detected in fetal livers

homeostasis/metabolism

edema ( J:117725 )

• most embryos show a subcutaneous edema at E15.5

liver/biliary system

small liver ( J:117725 )

• fetal livers are smaller than littermates

nervous system

incomplete rostral neuropore closure ( J:117725 )

• hindbrain region of embryos show incomplete anterior neural tube closure between E115-13.5

abnormal brain development ( J:117725 )

• mutant brains at E13.5-15.5 fail to develop further

exencephaly ( J:117725 )

• between E10.5 and 13.5, ~30% of embryos display exencephaly in forebrain, midbrain, and hindbrain regions

skeleton

abnormal mandible morphology ( J:117725 )

• mutants achieving skull closure demonstrated retarded mandible development

abnormal maxilla morphology ( J:117725 )

• mutants achieving skull closure demonstrated retarded maxilla development