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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park2tm1Ykt
targeted mutation 1, Yasuko Kitao
MGI:3698054
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park2tm1Ykt/Park2tm1Ykt involves: 129P2/OlaHsd * C57BL/6 MGI:3699152
cx2
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0
involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3814329
cx3
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3814331
cx4
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3814328
cx5
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
involves: 129P2/OlaHsd * C57BL/6 MGI:3814330


Genotype
MGI:3699152
hm1
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• slight increase in striatal dopamine level
• elevation of GPR37 levels by injection adeno-viral expression vectors results in increased dopaminergic neuronal cell death of cells in the substantia nigra pars compacta
• however, in untreated mice the number of dopaminergic neurons is similar to controls

growth/size/body
• slight decrease in body weight

homeostasis/metabolism
• slight increase in striatal dopamine level




Genotype
MGI:3814329
cx2
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (17 available)
Tg(Prp-GPR37)1Ryot mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 24 months
• in young animals
• at 18 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

cellular
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice
• mice exhibit an age-dependent increase in the levels of a marker of oxidative damage in the midbrain region
• however, mice do exhibit oxidative damage in the cortex region

behavior/neurological
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism
• by 24 months
• in young animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326




Genotype
MGI:3814331
cx3
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (17 available)
Tg(Prp-GPR37)1Ryot mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 24 months
• in young animals
• at 12 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
• at 6 months of age, mice exhibit a reduction in the number of TH+ neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis
• however, mice do not exhibit a change in hippocampal neurons at 24 months of age

cellular
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice

behavior/neurological
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism
• by 24 months
• in young animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326




Genotype
MGI:3814328
cx4
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (17 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 18 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326




Genotype
MGI:3814330
cx5
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (17 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
N
• mice exhibit normal behaviors

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory