Mouse Genome Informatics
hm1
    Park2tm1Ykt/Park2tm1Ykt
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• slight increase in striatal dopamine level
• elevation of GPR37 levels by injection adeno-viral expression vectors results in increased dopaminergic neuronal cell death of cells in the substantia nigra pars compacta
• however, in untreated mice the number of dopaminergic neurons is similar to controls

growth/size
• slight decrease in body weight

homeostasis/metabolism
• slight increase in striatal dopamine level


Mouse Genome Informatics
cx2
    Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0

involves: 129P2/OlaHsd * C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• by 24 months
• in young animals
• at 18 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

cellular
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice
• mice exhibit an age-dependent increase in the levels of a marker of oxidative damage in the midbrain region
• however, mice do exhibit oxidative damage in the cortex region

behavior/neurological
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors (J:140326)

homeostasis/metabolism
• by 24 months
• in young animals

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326


Mouse Genome Informatics
cx3
    Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot

involves: 129P2/OlaHsd * C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• by 24 months
• in young animals
• at 12 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
• however, mice do not exhibit a change in hippocampal neurons at 24 months of age
• at 6 months of age, mice exhibit a reduction in the number of TH+ neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

cellular
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice

behavior/neurological
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors (J:140326)

homeostasis/metabolism
• by 24 months
• in young animals

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326


Mouse Genome Informatics
cx4
    Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 18 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
N
• mice exhibit normal behaviors (J:140326)

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326


Mouse Genome Informatics
cx5
    Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological
N
• mice exhibit normal behaviors (J:140326)

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:140326