Analysis Tools
behavior/neurological
| N |
• despite increased amyloid protein levels, learning and memory behaviors are normal
• no changes in anxiety related behaviors or general locomotive activity are detected
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• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials
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• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected
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• mice are subordinated under competitive feeding conditions
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• mice bury significantly fewer marbles than wild-type mice in the marble burying test
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• mice displace significantly fewer food pellets from a tube in a burrowing test
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• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test
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nervous system
| N |
• no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release
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growth/size/body
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• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected
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homeostasis/metabolism
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• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT
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• significantly higher serotonin levels in the hypothalamus and somatosensory cortex
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | Alzheimer's disease | DOID:10652 | J:148481 | |
