• despite increased amyloid protein levels, learning and memory behaviors are normal (J:148481)

• no changes in anxiety related behaviors or general locomotive activity are detected (J:148481)

• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen

• however, under noncompetitive conditions no differences in food consumption or body weight are detected

• mice bury significantly fewer marbles than wild-type mice in the marble burying test

• mice are subordinated under competitive feeding conditions

• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials

• mice displace significantly fewer food pellets from a tube in a burrowing test

• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test

• no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release (J:148481)

• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen

• however, under noncompetitive conditions no differences in food consumption or body weight are detected

• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT

• significantly higher in the hypothalamus and somatosensory cortex

• with or without DOX administration, adult mice bury significantly more marbles than null mice in the marble burying test

• DOX administration to parental mice results in progeny which bury significantly fewer marbles than wild-type mice in the marble burying test

• without DOX administration mice displace significantly more food pellets from a tube than null mice in a burrowing test

• with or without DOX administration mice have decreased locomotor activity

• without DOX administration total number of resident social interactions with intruder mice are significantly increased compared to null mice in a resident-intruder test