Mouse Genome Informatics
hm1
    Apba2tm1Tsuz/Apba2tm1Tsuz
C57BL/6-Apba2tm1Tsuz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• despite increased amyloid protein levels, learning and memory behaviors are normal (J:148481)
• no changes in anxiety related behaviors or general locomotive activity are detected (J:148481)
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected
• mice bury significantly fewer marbles than wild-type mice in the marble burying test
• mice are subordinated under competitive feeding conditions
• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials
• mice displace significantly fewer food pellets from a tube in a burrowing test
• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test

nervous system
N
• no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release (J:148481)

growth/size
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected

homeostasis/metabolism
• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT
• significantly higher in the hypothalamus and somatosensory cortex

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Alzheimer Disease; AD 104300 J:148481


Mouse Genome Informatics
cx2
    Apba2tm1Tsuz/Apba2tm1Tsuz
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APBA2,-lacZ)1Ito/0

B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• with or without DOX administration, adult mice bury significantly more marbles than null mice in the marble burying test
• DOX administration to parental mice results in progeny which bury significantly fewer marbles than wild-type mice in the marble burying test
• without DOX administration mice displace significantly more food pellets from a tube than null mice in a burrowing test
• with or without DOX administration mice have decreased locomotor activity
• without DOX administration total number of resident social interactions with intruder mice are significantly increased compared to null mice in a resident-intruder test