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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apba2tm1Tsuz
targeted mutation 1, Toshiharu Suzuki
MGI:3697454
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apba2tm1Tsuz/Apba2tm1Tsuz C57BL/6-Apba2tm1Tsuz MGI:3697817
cx2
Apba2tm1Tsuz/Apba2tm1Tsuz
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APBA2,-lacZ)1Ito/0
B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito MGI:4418496


Genotype
MGI:3697817
hm1
Allelic
Composition
Apba2tm1Tsuz/Apba2tm1Tsuz
Genetic
Background
C57BL/6-Apba2tm1Tsuz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba2tm1Tsuz mutation (0 available); any Apba2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• despite increased amyloid protein levels, learning and memory behaviors are normal
• no changes in anxiety related behaviors or general locomotive activity are detected
• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected
• mice are subordinated under competitive feeding conditions
• mice bury significantly fewer marbles than wild-type mice in the marble burying test
• mice displace significantly fewer food pellets from a tube in a burrowing test
• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test

nervous system
N
• no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release

growth/size/body
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected

homeostasis/metabolism
• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT
• significantly higher in the hypothalamus and somatosensory cortex

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Alzheimer Disease; AD 104300 J:148481




Genotype
MGI:4418496
cx2
Allelic
Composition
Apba2tm1Tsuz/Apba2tm1Tsuz
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic
Background
B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba2tm1Tsuz mutation (0 available); any Apba2 mutation (16 available)
Tg(Camk2a-tTA)1Mmay mutation (7 available)
Tg(tetO-APBA2,-lacZ)1Ito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• with or without DOX administration, adult mice bury significantly more marbles than null mice in the marble burying test
• DOX administration to parental mice results in progeny which bury significantly fewer marbles than wild-type mice in the marble burying test
• without DOX administration mice displace significantly more food pellets from a tube than null mice in a burrowing test
• with or without DOX administration mice have decreased locomotor activity
• without DOX administration total number of resident social interactions with intruder mice are significantly increased compared to null mice in a resident-intruder test





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory