All Phenotypes Csrp2<tm1Sfy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Csrp2^tm1Sfy
targeted mutation 1, Shaw-Fang Yet
MGI:3697317

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csrp2^tm1Sfy/Csrp2^tm1Sfy	B6.129S2-Csrp2^tm1Sfy	MGI:3697459
hm2	Csrp2^tm1Sfy/Csrp2^tm1Sfy	involves: 129S2/SvPas	MGI:5007648
cx3	Csrp1^tm1Mbk/Csrp1^tm1Mbk Csrp2^tm1Sfy/Csrp2^tm1Sfy	involves: 129 * 129S2/SvPas * C57BL/6	MGI:5007647

Allelic Composition	Csrp2^tm1Sfy/Csrp2^tm1Sfy
Genetic Background	B6.129S2-Csrp2^tm1Sfy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csrp2^tm1Sfy mutation (0 available); any Csrp2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular smooth muscle physiology ( J:117557 )

• vascular smooth muscle cells migrate more rapidly in response to PDGF-BB and have increased Rac1 activation

abnormal vascular wound healing ( J:117557 )

• exhibit increased neointima formation following arterial injury, however, do not have any gross vascular defects under basal conditions

muscle

abnormal vascular smooth muscle physiology ( J:117557 )

• vascular smooth muscle cells migrate more rapidly in response to PDGF-BB and have increased Rac1 activation

homeostasis/metabolism

abnormal vascular wound healing ( J:117557 )

• exhibit increased neointima formation following arterial injury, however, do not have any gross vascular defects under basal conditions

Allelic Composition	Csrp2^tm1Sfy/Csrp2^tm1Sfy
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csrp2^tm1Sfy mutation (0 available); any Csrp2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:172149 )

• following wire-induced arterial injury, mice exhibit increased neointima formation compared to in wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:172149 )

• following wire-induced arterial injury, mice exhibit increased neointima formation compared to in wild-type mice

Allelic Composition	Csrp1^tm1Mbk/Csrp1^tm1Mbk Csrp2^tm1Sfy/Csrp2^tm1Sfy
Genetic Background	involves: 129 * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csrp1^tm1Mbk mutation (0 available); any Csrp1 mutation (19 available)
Csrp2^tm1Sfy mutation (0 available); any Csrp2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:172149 )

N	• following wire-induced arterial injury, mice exhibit normal neointima formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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