Phenotypes associated with this allele

• Allele Symbol: Crb1^tm2Wij
• Allele Name: targeted mutation 2, Jan Wijnholds
• Allele ID: MGI:3696955
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crb1^tm2Wij/Crb1^tm2Wij	either: B6.129P2-Crb1^tm2Wij or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3697462
ht2	Crb1^tm1Wij/Crb1^tm2Wij	involves: 129P2/OlaHsd * C57BL/6	MGI:3697463

Genotype
MGI:3697462

hm1

• Allelic Composition: Crb1^tm2Wij/Crb1^tm2Wij
• Genetic Background: either: B6.129P2-Crb1^tm2Wij or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:117415 )

• no homozygotes found, no specific time of death was indicated

Genotype
MGI:3697463

ht2

• Allelic Composition: Crb1^tm1Wij/Crb1^tm2Wij
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

vision/eye

abnormal retina morphology ( J:117415 )

• at 18 months of age autofluorescent dots are seen in 5 of 6 mice but not in any control mice

• however, no abnormalities in electroretinograms are detected at 3, 8, 12,18, or 30 months of age

abnormal retina inner nuclear layer morphology ( J:117415 )

• in mice older than 8 months of age dark stained nuclei are detected in the apical part of the inner nuclear layer in areas where the outer nuclear layer is folded

abnormal retina outer nuclear layer morphology ( J:117415 )

• in some mice older than 8 months of age areas of the outer nuclear layer are folded

• mild light exposure (3000 lux for 72 h) increases the incidence of mice with folds at 8 and 12 months of age, but not at 3 months of age

thin retina outer nuclear layer ( J:117415 )

• at 18 and 24 months of age the outer nuclear layer is significantly thinner compared to controls

abnormal retina photoreceptor layer morphology ( J:117415 )

retina fold ( J:117415 )

• in some mice older than 8 months of age areas of the outer nuclear layer are folded

• mild light exposure (3000 lux for 72 h) increases the incidence of mice with folds at 8 and 12 months of age, but not at 3 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 12		DOID:0110358	OMIM:600105	J:117415