Phenotypes associated with this allele

• Allele Symbol: Atp1a3^tm1Ling
• Allele Name: targeted mutation 1, Jerry B Lingrel
• Allele ID: MGI:3696954
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp1a3^tm1Ling/Atp1a3^tm1Ling	involves: 129 * Black Swiss	MGI:3697484
ht2	Atp1a3^tm1Ling/Atp1a3^+	involves: 129 * Black Swiss	MGI:3697485
ht3	Atp1a3^Myk/Atp1a3^tm1Ling	involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr	MGI:4356172

Genotype
MGI:3697484

hm1

• Allelic Composition: Atp1a3^tm1Ling/Atp1a3^tm1Ling
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:117414 )

• die shortly after birth

Genotype
MGI:3697485

ht2

• Allelic Composition: Atp1a3^tm1Ling/Atp1a3⁺
• Genetic Background: involves: 129 * Black Swiss

behavior/neurological

enhanced behavioral response to addictive substance ( J:117414 )

• increase in peak activity elicited by methamphetamine

abnormal spatial learning ( J:117414 )

• increased latency to find the platform in a Morris water maze

hyperactivity ( J:117414 )

• significant increase in activity in the first 4 time intervals in an open field

• increase in peak activity elicited by methamphetamine

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:117414 )

N • circulating levels of corticosterone, norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice

Genotype
MGI:4356172

ht3

• Allelic Composition: Atp1a3^Myk/Atp1a3^tm1Ling
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

mortality/aging

premature death ( J:151948 )

• no mice were present at 4 weeks (time of death not given)