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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdh1tm5(Cdh2)Kem
targeted mutation 5, Rolf Kemler
MGI:3696713
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem involves: 129P2/OlaHsd * C57BL/6 MGI:3697487
ht2
Cdh1tm2Kem/Cdh1tm5(Cdh2)Kem involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3697488


Genotype
MGI:3697487
hm1
Allelic
Composition
Cdh1tm5(Cdh2)Kem/Cdh1tm5(Cdh2)Kem
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm5(Cdh2)Kem mutation (0 available); any Cdh1 mutation (167 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos are recovered between E5.5 And 7.5; empty deciduae or deciduae filled with cellular debris are observed

embryo
• homozygous embryos do not hatch and many cells vacuolize and die
• outer cells of blastocyst round up with clearly reduced cell-cell contacts
• mutant show loosening of cell-cell contacts, form no blastocyst cavity or form small cyst-like cavities when an outer layerseparate from the inner layer
• between 3.5 and 4.5 homozygotes cannot form intact trophectoderm

reproductive system
• empty deciduae or deciduae filled with cellular debris are observed




Genotype
MGI:3697488
ht2
Allelic
Composition
Cdh1tm2Kem/Cdh1tm5(Cdh2)Kem
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (167 available)
Cdh1tm5(Cdh2)Kem mutation (0 available); any Cdh1 mutation (167 available)
phenotype observed in females
phenotype observed in males
N normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory