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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp3tm1Tch
targeted mutation 1, Talal A Chatila
MGI:3696705
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Foxp3tm1Tch/Foxp3+ C.129X1-Foxp3tm1Tch MGI:3697515
cx2
Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Foxp3tm1Tch MGI:3697518
ot3
Foxp3tm1Tch/Y B6.129X1-Foxp3tm1Tch MGI:3697517
ot4
Foxp3tm1Tch/Y C.129X1-Foxp3tm1Tch MGI:3697516


Genotype
MGI:3697515
ht1
Allelic
Composition
Foxp3tm1Tch/Foxp3+
Genetic
Background
C.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile with no signs of lymphoproliferative disorders




Genotype
MGI:3697518
cx2
Allelic
Composition
Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background
C.129-Stat6tm1Gru Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (53 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is increased to 23 days; however the upper limit of survival span is not increased compared to Foxp3 single hemizygotes

immune system
N
• normalized levels of IgE
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
• profoundly impaired production of Th2 cytokines and enhanced production of Th1 cytokines

respiratory system
N
• goblet cell metaplasia in the lungs is absent

hematopoietic system
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes

homeostasis/metabolism




Genotype
MGI:3697517
ot3
Allelic
Composition
Foxp3tm1Tch/Y
Genetic
Background
B6.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: survival is longer than in mice on a BALB/c background

immune system
• marked blood eosinophilia
• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls
• multisystem lymphoproliferative and myeloproliferative disease similar to mice on a BALB/c background
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
• prominent

hematopoietic system
• marked blood eosinophilia
• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls

respiratory system
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction

integument
• prominent




Genotype
MGI:3697516
ot4
Allelic
Composition
Foxp3tm1Tch/Y
Genetic
Background
C.129X1-Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• massive splenomegaly at 2 weeks of age

mortality/aging
• median survival is 16.5 days (J:117165)
• Background Sensitivity: survival is shorter than in mice on a C57BL/6 background (J:117165)
• hemizygous males develop lymphoproliferative disease with median survival of ~15 days of age, similar to Foxp3tm3Tch males (J:120636)

immune system
• massive splenomegaly at 2 weeks of age
• absence of CD4+ CD25+ regulatory T cells
• marked blood eosinophilia
• marked expansion of CD4+ cell populations
• marked expansion of CD8+ cell populations
• significant proportion of CD4+ and CD8+ cell populations are activated
• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
• hyperimmunoglobulinemia E
• striking increase in IgG1
• elevated levels of IL-10
• elevated levels of IL-4
• elevated levels of IL-5
• elevated levels of IL-6
• elevated levels of chemotactic factor monocyte chemotactic protein 1
• nonselective dysregulated production of both Th1 and Th2 cytokines
• mixed inflammatory infiltrate containing lymphocytes, neutrophils, monocytes, and eosinophils is found in the liver, stomach, pancreas, and skin
• an eosinophilic and neutrophilic infiltration is found in the gastrointestinal tract
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
• prominent

hematopoietic system
• massive splenomegaly at 2 weeks of age
• absence of CD4+ CD25+ regulatory T cells
• marked blood eosinophilia
• marked expansion of CD4+ cell populations
• marked expansion of CD8+ cell populations
• significant proportion of CD4+ and CD8+ cell populations are activated
• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
• hyperimmunoglobulinemia E
• striking increase in IgG1

digestive/alimentary system
• seen at 2 weeks of age

respiratory system
• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
• goblet cell metaplasia in the lungs

endocrine/exocrine glands
• seen at 2 weeks of age

homeostasis/metabolism
• elevated levels of IL-10
• elevated levels of IL-4
• elevated levels of IL-5
• elevated levels of IL-6
• elevated levels of chemotactic factor monocyte chemotactic protein 1

integument
• prominent





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory