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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1Hjf
targeted mutation 1, Hans Jorg Fehling
MGI:3696099
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cpa3tm3(icre)Hrr/Cpa3+
Gt(ROSA)26Sortm1Hjf/?
Notch1tm1Agt/Notch1tm1Agt
involves: 129 * C57BL/6 MGI:3829973
cn2
Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563102
cn3
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(CMV-cre)1Cgn/0
involves: 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3696483
cn4
Gt(ROSA)26Sortm1Hjf/?
Tg(Lck-cre)548Jxm/0
involves: C57BL/6 * SJL MGI:3696482


Genotype
MGI:3829973
cn1
Allelic
Composition
Cpa3tm3(icre)Hrr/Cpa3+
Gt(ROSA)26Sortm1Hjf/?
Notch1tm1Agt/Notch1tm1Agt
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpa3tm3(icre)Hrr mutation (0 available); any Cpa3 mutation (23 available)
Gt(ROSA)26Sortm1Hjf mutation (4 available); any Gt(ROSA)26Sor mutation (745 available)
Notch1tm1Agt mutation (0 available); any Notch1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors
• recombined Tcrb Dbeta1-Jbeta1 gene segments are detectable in some thymic plasmacytoid dendritic cells and lymphoid dendritic cells

hematopoietic system
• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors
• recombined Tcrb Dbeta1-Jbeta1 gene segments are detectable in some thymic plasmacytoid dendritic cells and lymphoid dendritic cells

cellular
• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors




Genotype
MGI:5563102
cn2
Allelic
Composition
Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (53 available)
Gt(ROSA)26Sortm1Hjf mutation (4 available); any Gt(ROSA)26Sor mutation (745 available)
Itchtm1.1Alta mutation (0 available); any Itch mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• regulatory T cells exhibit normal suppressive functions and stability




Genotype
MGI:3696483
cn3
Allelic
Composition
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (9 available); any Gt(ROSA)26Sor mutation (745 available)
Gt(ROSA)26Sortm1Hjf mutation (4 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(CMV-cre)1Cgn mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• analysis of hematopoietic cells demonstrates reliable detection of YFP and RFP in same cells as well as in different cells




Genotype
MGI:3696482
cn4
Allelic
Composition
Gt(ROSA)26Sortm1Hjf/?
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Hjf mutation (4 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable; strong variation in percentage of RFP-positive T lymphocytes is observed between individual mice, as well as activation in non-T lineage cells





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory