All Phenotypes Brca1<tm1Brn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm1Brn
targeted mutation 1, Anton Berns
MGI:3696057

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Brca1^tm1Brn/Brca1^tm1Brn	involves: 129P2/OlaHsd	MGI:3696695
cn2	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd	MGI:3696696
cn3	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:5617496
cn4	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:3762188
cn5	Brca1^tm1Brn/Brca1^tm1Brn Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:3762189
cn6	Brca1^tm1Brn/Brca1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:3762186
cn7	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:3762187
cn8	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5617499
cn9	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:5307257
cn10	Brca1^tm1Brn/Brca1^tm1.1Jjon Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:5307256

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell death ( J:117113 )

• after adenoviral cre infection, OSE cells in culture show significantly higher sensitivity to cisplatin treatment compared to control cells (47.3% remain ater 48 hours compared to 66.2% of control cells remaining)

decreased cell proliferation ( J:117113 )

• cultured cre-infected ovarian surface epithelium (OSE) cells show slower growth than GFP-injected cells at 96 and 120 hours post injection; at 120 hours, cell numbers are decreased by 40% compared to controls

endocrine/exocrine glands

abnormal ovary morphology ( J:117113 )

• after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection

• there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection

reproductive system

abnormal ovary morphology ( J:117113 )

• after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection

• there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell proliferation ( J:117113 )

• after adenoviral cre treatment, double mutant OSE cells show significantly enhanced proliferation compared to control cells

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm2Tyj mutation (4 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

increased metastatic potential ( J:189304 )

• distant metastases are seen in the pleura of 87.5%, in the lung of 83% and in the liver of 46% of mutants intrabursally injected with Ad-cre that develop stage IV disease

increased carcinoma incidence ( J:189304 )

• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

reproductive system

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

abnormal oviduct morphology ( J:189304 )

• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

• oviduct lesions are characterized by a glandular/acinar histology

homeostasis/metabolism

hemorrhagic ascites ( J:189304 )

• ovaries in intrabursally Ad-cre injected mice show hemorrhagic or serous ascites

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:126551

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Tg(KRT14-cre)8Brn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:126551 )

N	• mice fail to develop mammary gland tumors over 800 days of observation

Allelic Composition	Brca1^tm1Brn/Brca1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 332 days

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 332 days

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 332 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:126551

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:126551

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:178595 )

• compared to KB1C61GP littermate controls

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

increased skin tumor incidence ( J:178595 )

• compared to KB1C61GP littermate controls

abnormal tumor pathology ( J:178595 )

• in transplanted tumors response to olaparib treatment is improved compared to KB1C61GP littermate controls and KP mice

• transplanted tumors never develop resistance to cisplatin unlike tumors from KP mice

abnormal tumor morphology ( J:178595 )

• increased genomic instability in tumors compared to mice homozygous for Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)

increased tumor latency ( J:178595 )

• median latency is 236 days compared to 197 days in littermate controls heterozygous for Brca1^tm1Brn and Brca1^tm1.1Jjon, homozygous for Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1C61GP)

integument

increased mammary gland tumor incidence ( J:178595 )

• compared to KB1C61GP littermate controls

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

increased skin tumor incidence ( J:178595 )

• compared to KB1C61GP littermate controls

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178595 )

• compared to KB1C61GP littermate controls

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:178595

Allelic Composition	Brca1^tm1Brn/Brca1^tm1.1Jjon Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1.1Jjon mutation (0 available); any Brca1 mutation (113 available)
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

decreased skin tumor incidence ( J:178595 )

• markedly lower incidence compared to KB1P littermate controls

abnormal tumor pathology ( J:178595 )

• in transplanted tumors response to olaparib treatment is impaired compared to KB1P littermate controls but better than in KP mice

• transplanted tumors develop resistance to cisplatin and survival of transplanted mice is worse than that of mice transplanted with tumors from KB1P mice

abnormal tumor morphology ( J:178595 )

• increased genomic instability in tumors compared to mice homozygous for Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)

decreased tumor latency ( J:178595 )

• median latency is 197 days compared to 236 days in littermate controls homozygous for Brca1^tm1Brn Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1P)

• however, no difference in the latency of mammary tumor development

integument

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

decreased skin tumor incidence ( J:178595 )

• markedly lower incidence compared to KB1P littermate controls

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:178595

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