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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Krt4Bcc1
bright coat color 1
MGI:3695408
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Krt4Bcc1/Krt4Bcc1 C3HeB/FeJ-Krt4Bcc1 MGI:3695719
ht2
Krt4Bcc1/Krt4+ C3HeB/FeJ-Krt4Bcc1 MGI:3695720


Genotype
MGI:3695719
hm1
Allelic
Composition
Krt4Bcc1/Krt4Bcc1
Genetic
Background
C3HeB/FeJ-Krt4Bcc1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt4Bcc1 mutation (0 available); any Krt4 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slight but significant reduction in survival

craniofacial
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

digestive/alimentary system
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

growth/size/body
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable
• runted and underdeveloped by 2 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
White Sponge Nevus 1; WSN1 193900 J:116740




Genotype
MGI:3695720
ht2
Allelic
Composition
Krt4Bcc1/Krt4+
Genetic
Background
C3HeB/FeJ-Krt4Bcc1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt4Bcc1 mutation (0 available); any Krt4 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• on the tongue
• milder than in homozygous mice
• thickened lingual mucosa with evidence of inter-papillar cytolysis

pigmentation
• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black
• difference in coat color is most visible around 4 weeks of age

craniofacial
• on the tongue
• milder than in homozygous mice
• thickened lingual mucosa with evidence of inter-papillar cytolysis

integument
• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black
• difference in coat color is most visible around 4 weeks of age

growth/size/body
• on the tongue
• milder than in homozygous mice
• thickened lingual mucosa with evidence of inter-papillar cytolysis

Mouse Models of Human Disease
OMIM ID Ref(s)
White Sponge Nevus 1; WSN1 193900 J:116740





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory