Mouse Genome Informatics
hm1
    Krt4Bcc1/Krt4Bcc1
C3HeB/FeJ-Krt4Bcc1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• slight but significant reduction in survival

craniofacial
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

digestive/alimentary system
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

growth/size/body
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable
• runted and underdeveloped by 2 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
White Sponge Nevus 1; WSN1 193900 J:116740


Mouse Genome Informatics
ht2
    Krt4Bcc1/Krt4+
C3HeB/FeJ-Krt4Bcc1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
digestive/alimentary system
• milder than in homozygous mice
• on the tongue
• thickened lingual mucosa with evidence of inter-papillar cytolysis

pigmentation
• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black
• difference in coat color is most visible around 4 weeks of age

craniofacial
• on the tongue
• milder than in homozygous mice
• thickened lingual mucosa with evidence of inter-papillar cytolysis

integument
• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black
• difference in coat color is most visible around 4 weeks of age

growth/size/body
• on the tongue
• milder than in homozygous mice
• thickened lingual mucosa with evidence of inter-papillar cytolysis

Mouse Models of Human Disease
OMIM IDRef(s)
White Sponge Nevus 1; WSN1 193900 J:116740