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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lyl1tm1Fsky
targeted mutation 1, Fred Sablitzky
MGI:3693950
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lyl1tm1Fsky/Lyl1tm1Fsky involves: 129P2/OlaHsd * C57BL/6 MGI:3694640


Genotype
MGI:3694640
hm1
Allelic
Composition
Lyl1tm1Fsky/Lyl1tm1Fsky
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyl1tm1Fsky mutation (0 available); any Lyl1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• myeloid and lymphoid cell numbers are normal in adults
• mice have reduced numbers of stem/progenitor B cells
• a partial block in differentiation is observed after the pro-B stage
• when mutant bone marrow is transplanted into irradiated recipients, reconstitution of T cell lineage is impaired
• platelet cell numbers are significantly reduced in adults
• markedly reduced (1-3-fold) in peripheral blood, bone marrow and spleen in adults
• stem cells with a limited ability to engraft recipients noticed by 4 weeks
• repopulation is skewed toward myeloid cells
• short term repopulation potential is somewhat greater than in Lyl1tm1Mago

immune system
• mice have reduced numbers of stem/progenitor B cells
• a partial block in differentiation is observed after the pro-B stage
• when mutant bone marrow is transplanted into irradiated recipients, reconstitution of T cell lineage is impaired
• markedly reduced (1-3-fold) in peripheral blood, bone marrow and spleen in adults





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory