Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation
(1 available);
any
Slc17a6 mutation
(59 available)
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behavior/neurological
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• mice display decreased responsiveness to radiant heat but response to mechanically-induced pain is not significantly different from wild-type controls
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• mice have decreased sensitivity to inflammatory pain induced by formalin injection, but response to mechanically-induced pain is not different from wild-type
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• latency of withdrawal in hot plate tests is significantly greater than wild-type at both 52 and 48 degrees
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homeostasis/metabolism
integument
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• immune cells are found in the dermis in wounded areas indicative of prolonged scratching and rubbing
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• mice display thickened epidermis of psoriasiform type in wounded areas
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• mice develop lesions (ulcerations) in the neck and upper back region
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• mice display a chronic itch behavior (display frequent scratching episodes)
• topical application of a histamine receptor antagonist significantly reduces scratching behavior; oral administration of a blood-brain barrier impermeant antihistamine causes a similar reduction in scratching
• topical administration of capsaicin reduces the itch phenotype
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation
(1 available);
any
Slc17a6 mutation
(59 available)
Tg(PLAT-cre)116Sdu mutation
(0 available)
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behavior/neurological
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• mice display decreased responsiveness to radiant heat
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integument
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• mice display a chronic itch behavior (display frequent scratching episodes)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation
(1 available);
any
Slc17a6 mutation
(59 available)
Tg(Trpv1-icre)1Kldr mutation
(0 available)
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behavior/neurological
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• scratching behavior is significantly elevated compared to controls
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• mice show decreased thermal pain sensitivity, but mechanical pain and inflammatory pain sensitivities are not different from control
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behavior/neurological
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• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function
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behavior/neurological
N |
• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response
• in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed
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