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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc17a6tm1Kldr
targeted mutation 1, Klas Kullander
MGI:3693864
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc17a6tm1Kldr/Slc17a6tm1Kldr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3694902
cn2
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887826
cn3
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Tg(PLAT-cre)116Sdu/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887827
cn4
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Tg(Trpv1-icre)1Kldr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887828
cn5
Grprtm1Jfb/Grprtm1Jfb
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887830
cn6
Scn10atm2(cre)Jwo/Scn10a+
Slc17a6tm1Kldr/Slc17a6tm1Kldr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887831


Genotype
MGI:3694902
hm1
Allelic
Composition
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile




Genotype
MGI:4887826
cn2
Allelic
Composition
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
Thtm1(cre)Te mutation (1 available); any Th mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice display decreased responsiveness to radiant heat but response to mechanically-induced pain is not significantly different from wild-type controls
• mice have decreased sensitivity to inflammatory pain induced by formalin injection, but response to mechanically-induced pain is not different from wild-type
• latency of withdrawal in hot plate tests is significantly greater than wild-type at both 52 and 48 degrees

homeostasis/metabolism
N
• plasma creatinine, urea, and tyroxine 4 levels are normal, with slightly elevated by still within normal range levels of alanine aminotransferase; this excludes a systemic disorder (chronic itch) as underlying the elevated scratching

integument
• immune cells are found in the dermis in wounded areas indicative of prolonged scratching and rubbing
• mice display thickened epidermis of psoriasiform type in wounded areas
• mice develop lesions (ulcerations) in the neck and upper back region
• mice display a chronic itch behavior (display frequent scratching episodes)
• topical application of a histamine receptor antagonist significantly reduces scratching behavior; oral administration of a blood-brain barrier impermeant antihistamine causes a similar reduction in scratching
• topical administration of capsaicin reduces the itch phenotype




Genotype
MGI:4887827
cn3
Allelic
Composition
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Tg(PLAT-cre)116Sdu/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
Tg(PLAT-cre)116Sdu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice display decreased responsiveness to radiant heat

integument
• mice display a chronic itch behavior (display frequent scratching episodes)




Genotype
MGI:4887828
cn4
Allelic
Composition
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Tg(Trpv1-icre)1Kldr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
Tg(Trpv1-icre)1Kldr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• scratching behavior is significantly elevated compared to controls
• mice show decreased thermal pain sensitivity, but mechanical pain and inflammatory pain sensitivities are not different from control




Genotype
MGI:4887830
cn5
Allelic
Composition
Grprtm1Jfb/Grprtm1Jfb
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
Thtm1(cre)Te mutation (1 available); any Th mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function




Genotype
MGI:4887831
cn6
Allelic
Composition
Scn10atm2(cre)Jwo/Scn10a+
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10atm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response
• in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory