All Phenotypes Trp63<tm2Fmc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp63^tm2Fmc
targeted mutation 2, Frank McKeon
MGI:3693853

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp63^tm2Fmc/Trp63^tm2Fmc	involves: BALB/c	MGI:3706345

Allelic Composition	Trp63^tm2Fmc/Trp63^tm2Fmc
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63^tm2Fmc mutation (0 available); any Trp63 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:116176 )

• after exposure to 0.45 Gy radiation on P5, ovaries of mutants show no oocyte death compared to ~90% observed in wild-type and Trp53^tm1Tyj homozygotes

• oocytes in primordial follicles are completely resistant to DNA damage-induced oocyte death

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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