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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APPSwLon)96Btla
transgene insertion 96, Bruce Lamb
MGI:3693359
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S4/SvJae MGI:3693492
tg2
Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla involves: 129S4/SvJae MGI:3693506
tg3
Tg(APPSwLon)96Btla/0 involves: 129S4/SvJae MGI:3693440


Genotype
MGI:3693492
cx1
Allelic
Composition
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

homeostasis/metabolism
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged




Genotype
MGI:3693506
tg2
Allelic
Composition
Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes

homeostasis/metabolism
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes




Genotype
MGI:3693440
tg3
Allelic
Composition
Tg(APPSwLon)96Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

homeostasis/metabolism
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:42613





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory