Mouse Genome Informatics
cx1
    Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0

involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

other phenotype
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged


Mouse Genome Informatics
tg2
    Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes (J:58050)
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes

other phenotype
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes


Mouse Genome Informatics
tg3
    Tg(APPSwLon)96Btla/0
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes (J:58050)
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

other phenotype
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:42613