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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APPSwLon)96Btla
transgene insertion 96, Bruce Lamb
MGI:3693359
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S4/SvJae MGI:3693492
tg2
Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla involves: 129S4/SvJae MGI:3693506
tg3
Tg(APPSwLon)96Btla/0 involves: 129S4/SvJae MGI:3693440


Genotype
MGI:3693492
cx1
Allelic
Composition
Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (1 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

homeostasis/metabolism
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged




Genotype
MGI:3693506
tg2
Allelic
Composition
Tg(APPSwLon)96Btla/Tg(APPSwLon)96Btla
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes

homeostasis/metabolism
• homzygous mice have 4- to 6-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes




Genotype
MGI:3693440
tg3
Allelic
Composition
Tg(APPSwLon)96Btla/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no Alzheimer's disease pathology is observed at 2 years of age in homozygotes
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

homeostasis/metabolism
• mice have much higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APPSw)40Btla mutant mice or Tg(APP)8.9Btla mice (J:42613)
• hemizygous mice have 2- to 3-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:42613





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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory