All Phenotypes Or8a1<tm27Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Or8a1^tm27Mom
targeted mutation 27, Peter Mombaerts
MGI:3692987

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Or8a1^tm27Mom/Or8a1^{tm40(Gnas*)Mom}	involves: 129P2/OlaHsd * C57BL/6	MGI:5788570
ht2	Or8a1^{tm43(Or8a1)Mom}/Or8a1^tm27Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:5788573
cn3	Gnas^tm5.1Lsw/Gnas^tm5.1Lsw Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}/Gt(ROSA)26Sor⁺ Or8a1^tm28(cre)Mom/Or8a1^tm27Mom	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5788923

Allelic Composition	Or8a1^tm27Mom/Or8a1^{tm40(Gnas*)Mom}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1^tm27Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1^{tm40(Gnas*)Mom} mutation (1 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:233447 )

• the RFP+ axons form compartmentalized glomeruli distinct from those formed by the GFP+ axons co-expressing constitutively active GNAS, indicating a changed axonal identity through expression of constitutively active GNAS

Allelic Composition	Or8a1^{tm43(Or8a1)Mom}/Or8a1^tm27Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1^tm27Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1^{tm43(Or8a1)Mom} mutation (1 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:233447 )

• compartmentalized glomeruli are often found, with the RFP+ axons and GFP+ axons separating into separate glomeruli, indicating a change in axonal identity through doubled expression of OLFR151 levels in the GFP+ axons.

Allelic Composition	Gnas^tm5.1Lsw/Gnas^tm5.1Lsw Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe}/Gt(ROSA)26Sor⁺ Or8a1^tm28(cre)Mom/Or8a1^tm27Mom
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas^tm5.1Lsw mutation (1 available); any Gnas mutation (53 available)
Gt(ROSA)26Sor^{tm1(CAG-Mapt/GFP)Uboe} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Or8a1^tm27Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1^tm28(cre)Mom mutation (2 available); any Or8a1 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

taste/olfaction phenotype ( J:233447 )

N	• axons of OLFR151 expressing olfactory sensory neurons appear to co-converge and coalesce in glomerular formation correctly despite G-protein disruption during development

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