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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Tnnt2)191Lnwd
transgene insertion 191, Leslie A Leinwand
MGI:3692603
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Tnnt2)191Lnwd/0 involves: C57BL/6 MGI:3719611


Genotype
MGI:3719611
tg1
Allelic
Composition
Tg(Myh6-Tnnt2)191Lnwd/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no hemizygous male that serves as a stud survived more than 13 months (J:48301)
• no hemizygous male that serves as a stud survived more than 13 months (J:48301)

cardiovascular system
• exhibit atrial wall thickening (J:48301)
• exhibit atrial wall thickening (J:48301)
• exhibit early dilatation of the atria (J:48301)
• exhibit early dilatation of the atria (J:48301)
• neonatal and adult hearts show myocellular disorganization and degeneration (J:48301)
• neonatal and adult hearts show myocellular disorganization and degeneration (J:48301)
• exhibit about 8-10% fewer myocytes than controls (J:48301)
• exhibit about 8-10% fewer myocytes than controls (J:48301)
• neonatal and adult hearts show myocellular degeneration (J:48301)
• neonatal and adult hearts show myocellular degeneration (J:48301)
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17% (J:48301)
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17% (J:48301)
• neonatal and adult hearts show myocellular disorganization (J:48301)
• neonatal and adult hearts show myocellular disorganization (J:48301)
• heart weight to body weight ratio shows an 18-27% decrease in heart mass at 4-5 months of age (J:48301)
• heart weight to body weight ratio shows an 18-27% decrease in heart mass at 4-5 months of age (J:48301)
• altering the physiologic load on the heart shows some impairment in contractility (J:48301)
• altering the physiologic load on the heart shows some impairment in contractility (J:48301)
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation (J:48301)
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time (J:48301)
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation (J:48301)
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time (J:48301)
• isolated adult cardiac myocytes and hypersensitive to calcium; addition of calcium led to immediate cellular hypercontracture and death (J:48301)
• isolated adult cardiac myocytes and hypersensitive to calcium; addition of calcium led to immediate cellular hypercontracture and death (J:48301)

muscle
• neonatal and adult hearts show myocellular disorganization and degeneration (J:48301)
• neonatal and adult hearts show myocellular disorganization and degeneration (J:48301)
• exhibit about 8-10% fewer myocytes than controls (J:48301)
• exhibit about 8-10% fewer myocytes than controls (J:48301)
• neonatal and adult hearts show myocellular degeneration (J:48301)
• neonatal and adult hearts show myocellular degeneration (J:48301)
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17% (J:48301)
• mean length and midpoint width of quiescent ventricular cardiac myocytes are 15 and 13% smaller, respectively, than in controls and mean myocyte area is decreased by 17% (J:48301)
• altering the physiologic load on the heart shows some impairment in contractility (J:48301)
• altering the physiologic load on the heart shows some impairment in contractility (J:48301)
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation (J:48301)
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time (J:48301)
• at a baseline workload, hearts exhibit a 25% decrease in the maximal rate of relaxation (J:48301)
• hearts show a moderately good correlation of +dP/dT to increased work, however the slope of the Starling curve is severely decreased during relaxation suggesting that hearts cannot respond to an increased work load by shortening their relaxation time (J:48301)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 2; CMH2 115195 J:48301





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory