All Phenotypes Ldlr<tm1(LDLR)Mae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ldlr^tm1(LDLR)Mae
targeted mutation 1, Nobuyo Maeda
MGI:3691296

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ldlr^tm1(LDLR)Mae/Ldlr⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:3695716
cx2	Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3695717
cx3	Apoe^{tm2(APOE3)Mae}/Apoe^{tm2(APOE3)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4355226
cx4	Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4355231

Allelic Composition	Ldlr^tm1(LDLR)Mae/Ldlr⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1(LDLR)Mae mutation (2 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating lipid level ( J:67282 )

• decrease in plasma lipid levels that is accompanied by reduction in plasma apoproteins B, E, and AI

decreased circulating cholesterol level ( J:67282 )

• females exhibit a 4-fold reduction in steady state plasma cholesterol when fed normal chow

• when fed a high fat diet, plasma cholesterol levels increase due mainly to the increase in HDL cholesterol, although levels are still lower than in wild-type on a high fat diet

decreased circulating HDL cholesterol level ( J:67282 )

Allelic Composition	Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^{tm1(APOE*2)Mae} mutation (2 available); any Apoe mutation (145 available)
Ldlr^tm1(LDLR)Mae mutation (2 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:67282 )

• exhibit increased clearance of non-HDL lipoproteins (VLDL and LDL) from plasma

decreased susceptibility to hyperlipidemia ( J:67282 )

• do not develop type III hyperlipoproteinemia, exhibiting normal plasma cholesterol and triglyceride levels on a normal chow diet

• more resistant to diet-induced hyperlipidemia than single Apoe^tm1(APOE)Mae homozygotes

Allelic Composition	Apoe^{tm2(APOE3)Mae}/Apoe^{tm2(APOE3)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^{tm2(APOE*3)Mae} mutation (2 available); any Apoe mutation (145 available)
Ldlr^tm1(LDLR)Mae mutation (2 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:146721 )

• very little plaque development

abnormal circulating lipid level ( J:146721 )

• significantly lower lipid levels on a normal fat diet

nervous system

amyloid beta deposits ( J:146721 )

• very little plaque development

Allelic Composition	Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae} Ldlr^tm1(LDLR)Mae/Ldlr⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^{tm3(APOE*4)Mae} mutation (3 available); any Apoe mutation (145 available)
Ldlr^tm1(LDLR)Mae mutation (2 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:146721 )

• significant plaque development on a high fat diet relative to Apoe^{tm2(APOE*3)Mae} mice who show very little plaque development

abnormal circulating lipid level ( J:146721 )

• significantly lower lipid levels on a normal fat diet

increased circulating cholesterol level ( J:146721 )

• greater increase in total cholesterol when fed a high fat diet than seen in Apoe^{tm2(APOE*3)Mae} mice

• very high total cholesterol to triglyceride ratio on a high fat diet

• increased number of non-HDL particles

• plasma cholesterol decrease over time relative to mice lacking Ldlr^tm1(LDLR)Mae

increased circulating triglyceride level ( J:146721 )

• higher triglyceride levels in females on a normal fat diet

nervous system

amyloid beta deposits ( J:146721 )

• significant plaque development on a high fat diet relative to Apoe^{tm2(APOE*3)Mae} mice who show very little plaque development

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