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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adgrl1tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:3691022
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adgrl1tm1Sud/Adgrl1tm1Sud involves: 129S6/SvEvTac * C57BL/6 MGI:3691029
cx2
Adgrl1tm1Sud/Adgrl1tm1Sud
Nrxn1tm1Sud/Nrxn1tm1Sud
involves: 129 * 129S6/SvEvTac * C57BL/6 MGI:3691278


Genotype
MGI:3691029
hm1
Allelic
Composition
Adgrl1tm1Sud/Adgrl1tm1Sud
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrl1tm1Sud mutation (1 available); any Adgrl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygous female mice fail adequately to care for their litters

nervous system
• in the absence of Ca2+, only about 25% as much 125I-alpha-latrotoxin binds to membranes isolated from brains of homozygous mutant mice as from wild-type mice
• in the presence of Ca2+, about 50% as much 125I-alpha-latrotoxin binds to brain membranes from homozygous mutant mice as from wild-type mice; binding in the presence of Ca2+ is approximately 2-fold that in its absence
• although the kinetics of K+-depolarization-stimulated glutamate release in the presence of Ca2+ from synaptosomes isolated from homozygous mutant and wild-type brains are similar, alpha-latrotoxin-stimulated glutamate release from synaptosomes of mutant brains is reduced to approximately 25% that from wild-type synaptosomes in the presence or absence of Ca2+




Genotype
MGI:3691278
cx2
Allelic
Composition
Adgrl1tm1Sud/Adgrl1tm1Sud
Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic
Background
involves: 129 * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrl1tm1Sud mutation (1 available); any Adgrl1 mutation (60 available)
Nrxn1tm1Sud mutation (1 available); any Nrxn1 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the presence or in the absence of Ca2+, the amount of 125I-alpha-latrotoxin binding to membranes isolated from brains of doubly homozygous mutant mice is reduced to about 25% of that binding to brain membranes from wild-type mice; approximately twice as much binds in the presence of Ca2+ as in its absence
• although in the presence of Ca2+ the kinetics are similar for alpha-latrotoxin-stimulated release of glutamate from doubly mutant and wild-type brain-derived synaptosomes, in the absence of Ca2+ the delay to initiation of glutamate release from doubly mutant synaptosomes is prolonged in comparison to that from wild-type and both singly mutant synaptosomes (5 min vs. 2 min)
• in the absence of Ca2+, alpha-latrotoxin-stimulated glutamate release from synaptosomes isolated from doubly homozygous mutant brains is reduced to approximately 50% of that from wild-type synaptosomes





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory