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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fkbp4tm1Shou
targeted mutation 1, Weinian Shou
MGI:3690438
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fkbp4tm1Shou/Fkbp4tm1Shou either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) MGI:3692934
hm2
Fkbp4tm1Shou/Fkbp4tm1Shou involves: 129S/SvEv MGI:3710989
cx3
Fkbp4tm1Shou/Fkbp4tm1Shou
Fkbp5Gt(RRC236)Byg/Fkbp5Gt(RRC236)Byg
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3710991
cx4
Fkbp4tm1Shou/Fkbp4tm1Shou
Fkbp5Gt(RRC236)Byg/Fkbp5+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3710992


Genotype
MGI:3692934
hm1
Allelic
Composition
Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic
Background
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp4tm1Shou mutation (0 available); any Fkbp4 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• uterus fails to undergo decidualization in response to progesterone and implantation trauma, but responds normally to estrogen (J:114715)
• uterus fails to undergo decidualization in response to progesterone and implantation trauma, but responds normally to estrogen (J:114715)
• fewer oocytes are obtained from pregnant mare serum gonadotropin/human chorionic gonadotropin-treated (superovulated) virgin females (J:114715)
• fewer oocytes are obtained from pregnant mare serum gonadotropin/human chorionic gonadotropin-treated (superovulated) virgin females (J:114715)
• homozygous females are sterile due to a complete failure of implantation (J:114715)
• homozygous females are sterile due to a complete failure of implantation (J:114715)

endocrine/exocrine glands
• exhibit a moderate reduction in mammary gland tertiary side branching and alveologenesis in response to administration of 17beta-estradiol and progesterone for 14 days after ovariectomy (J:114715)
• exhibit a moderate reduction in mammary gland tertiary side branching and alveologenesis in response to administration of 17beta-estradiol and progesterone for 14 days after ovariectomy (J:114715)

embryogenesis
• uterus fails to undergo decidualization in response to progesterone and implantation trauma, but responds normally to estrogen (J:114715)
• uterus fails to undergo decidualization in response to progesterone and implantation trauma, but responds normally to estrogen (J:114715)

integument
• exhibit a moderate reduction in mammary gland tertiary side branching and alveologenesis in response to administration of 17beta-estradiol and progesterone for 14 days after ovariectomy (J:114715)
• exhibit a moderate reduction in mammary gland tertiary side branching and alveologenesis in response to administration of 17beta-estradiol and progesterone for 14 days after ovariectomy (J:114715)




Genotype
MGI:3710989
hm2
Allelic
Composition
Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp4tm1Shou mutation (0 available); any Fkbp4 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal male reproductive anatomy in Fkbp4tm1Shou/Fkbp4tm1Shou mice

reproductive system
• shortened in mice 3 to 10 weeks of age (J:120960)
• shortened in mice 3 to 10 weeks of age (J:120960)
• feminization phenotype, similar to that seen in androgen receptor null mice, occurs less frequently (J:120960)
• however, primary sex organs (testes, epididymis, scrotal sac and inguinal canals) are normal (J:120960)
• feminization phenotype, similar to that seen in androgen receptor null mice, occurs less frequently (J:120960)
• however, primary sex organs (testes, epididymis, scrotal sac and inguinal canals) are normal (J:120960)
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)
• ectopic opening on the ventral side of the penis (J:120960)
• ectopic opening on the ventral side of the penis (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• females are infertile due to implantation failure (J:120960)
• females are infertile due to implantation failure (J:120960)
• males mated to wild-type females yield smaller litters (2.1+/-0.9 pups) compared to wild-type (6.8+/-1.6 pups) (J:120960)
• males mated to wild-type females yield smaller litters (2.1+/-0.9 pups) compared to wild-type (6.8+/-1.6 pups) (J:120960)
• male mice have greatly reduced fertility with only 5% of mice being able to plug females (J:120960)
• male mice have greatly reduced fertility with only 5% of mice being able to plug females (J:120960)
• slightly reduced (47.7+/-8.8 compared to 69.0+/-8.8 in wild-type) (J:120960)
• slightly reduced (47.7+/-8.8 compared to 69.0+/-8.8 in wild-type) (J:120960)

homeostasis/metabolism
• slightly increased serum testosterone and DHT levels (J:120960)
• slightly increased serum testosterone and DHT levels (J:120960)

growth/size/body
• males weigh less postnatally (J:120960)
• males weigh less postnatally (J:120960)
• males exhibit decreased growth rates compared to females and wild-type mice (J:120960)
• males exhibit decreased growth rates compared to females and wild-type mice (J:120960)

renal/urinary system
• ectopic opening on the ventral side of the penis (J:120960)
• ectopic opening on the ventral side of the penis (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• found in 100% of the external penile genitalia (J:120960)
• developmental defect resulting from the failure to form urethral seams (J:120960)
• found in 100% of the external penile genitalia (J:120960)
• developmental defect resulting from the failure to form urethral seams (J:120960)

digestive/alimentary system
• shortened in mice 3 to 10 weeks of age (J:120960)
• shortened in mice 3 to 10 weeks of age (J:120960)

endocrine/exocrine glands
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:120960




Genotype
MGI:3710991
cx3
Allelic
Composition
Fkbp4tm1Shou/Fkbp4tm1Shou
Fkbp5Gt(RRC236)Byg/Fkbp5Gt(RRC236)Byg
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp4tm1Shou mutation (0 available); any Fkbp4 mutation (17 available)
Fkbp5Gt(RRC236)Byg mutation (0 available); any Fkbp5 mutation (143 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die prior to E7.5 (J:120960)
• embryos die prior to E7.5 (J:120960)




Genotype
MGI:3710992
cx4
Allelic
Composition
Fkbp4tm1Shou/Fkbp4tm1Shou
Fkbp5Gt(RRC236)Byg/Fkbp5+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp4tm1Shou mutation (0 available); any Fkbp4 mutation (17 available)
Fkbp5Gt(RRC236)Byg mutation (0 available); any Fkbp5 mutation (143 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice develop hypospadia similar to Fkbp4tm1Shou homozygotes (J:120960)
• mice develop hypospadia similar to Fkbp4tm1Shou homozygotes (J:120960)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory