Analysis Tools
reproductive system
renal/urinary system
| N |
• Background Sensitivity: males on a 129 background do not exhibit hydronephrosis as is seen on a mixed 129 and C57BL/6J background
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Allele Symbol Allele Name Allele ID |
Hspa4ltm1Imad targeted mutation 1, Ibrahim M Adham MGI:3690321 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: males on a 129 background do not exhibit hydronephrosis as is seen on a mixed 129 and C57BL/6J background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit increased mortality after a 3% NaCl treatment, with all mutants dying on the third day of treatment while all wild-type survive
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• infertile males show a reduction in the proportions of motile and progressively motile sperm from the cauda epididymides
• fertile males show normal sperm concentrations but significantly reduced sperm motility
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• although seminiferous tubules contain all stages of germ cells, the number of mature sperm in the epididymis is reduced due to increased apoptosis of developing germ cells
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• infertile males show a significant reduction in the number of spermatozoa and increased apoptosis of germ cells
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• observe premature release of germ cells into the lumen
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• 42% of males produce no offspring but generate vaginal plugs in females, indicating males are capable of mating
• the males that do produce offspring, produce small litters
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• 12% of 4 to 8 month old males exhibit massive unilateral or bilateral fluid-filled kidneys, however the ureters are not enlarged or dilated
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• renal cortex is thinned in 12% of males
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• Background Sensitivity: 12% of 4 to 8 month old males on the mixed 129 and C57BL/6J background exhibit moderate to severe dilation of the renal pelvis, indicating hydronephrosis, compared to none on a 129 background
• in most cases, hydronephrosis is seen in the right kidney of males
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• hydronephrotic kidneys are accompanied by different degrees of atrophy of the renal parenchyma
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• kidneys exhibit increased susceptibility to osmotic stress, with mutants showing increased weight loss, mortality, and elevated plasma sodium, calcium, blood gases, and urea nitrogen after a 3% NaCl treatment
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• exhibit elevated blood urea nitrogen levels compared to wild-type after a 3% NaCl treatment
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• exhibit elevated plasma calcium levels compared to wild-type after a 3% NaCl treatment
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• exhibit elevated plasma sodium levels compared to wild-type after a 3% NaCl treatment
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• exhibit increased weight loss compared to wild-type after a 3% NaCl treatment
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• infertile males show a significant reduction in the number of spermatozoa and increased apoptosis of germ cells
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• infertile males show a reduction in the proportions of motile and progressively motile sperm from the cauda epididymides
• fertile males show normal sperm concentrations but significantly reduced sperm motility
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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