Phenotypes associated with this allele
Allelic Composition |
Chattm1(cre)Lowl/Chat+
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Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation
(1 available);
any
Chat mutation
(57 available)
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normal phenotype
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• heterozygotes are viable and fertile; cre recombinase activity is detected in all cholinergic neurons
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nervous system
N |
• type Ia proprioceptive sensory neuron projections grow normally to the ventral horn
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cardiovascular system
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• develop obesity induced hypertension but only during active period
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation
(1 available);
any
Chat mutation
(57 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Mc4rtm2Lowl mutation
(0 available);
any
Mc4r mutation
(44 available)
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nervous system
N |
• biophysical properties of cholinergic neurons are normal
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• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons
• similar results with Mc4r agonist THIQ
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