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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cftrtm3Mrc
targeted mutation 3, Mario R Capecchi
MGI:3688292
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cftrtm3Mrc/Cftrtm3Mrc B6.129S6-Cftrtm3Mrc MGI:3689381


Genotype
MGI:3689381
hm1
Allelic
Composition
Cftrtm3Mrc/Cftrtm3Mrc
Genetic
Background
B6.129S6-Cftrtm3Mrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm3Mrc mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• develop intestinal blockage when fed a normal (solid) diet

growth/size/body
• weighed significantly less (P 0.05) than homozygote wild-type controls at 14 and 21 days of age

immune system
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

mortality/aging
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

respiratory system
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• after treatment with a chloride-depleted solution with amiloride and forskolin, the nasal potential difference (PD) was significantly different between control mice and homozygous mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:112450





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory