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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cftrtm3Mrc
targeted mutation 3, Mario R Capecchi
MGI:3688292
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cftrtm3Mrc/Cftrtm3Mrc B6.129S6-Cftrtm3Mrc MGI:3689381


Genotype
MGI:3689381
hm1
Allelic
Composition
Cftrtm3Mrc/Cftrtm3Mrc
Genetic
Background
B6.129S6-Cftrtm3Mrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm3Mrc mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• develop intestinal blockage when fed a normal (solid) diet

growth/size/body
• weighed significantly less (P 0.05) than homozygote wild-type controls at 14 and 21 days of age

immune system
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

mortality/aging
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

respiratory system
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• after treatment with a chloride-depleted solution with amiloride and forskolin, the nasal potential difference (PD) was significantly different between control mice and homozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cystic fibrosis DOID:1485 OMIM:219700
J:112450





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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory