Mouse Genome Informatics
hm1
     Cftrtm3Mrc/Cftrtm3Mrc
B6.129S6-Cftrtm3Mrc
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
respiratory system
abnormal respiratory system physiology ( J:112450 )
• abnormal nasal potential difference
lung inflammation ( J:112450 )
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes

growth/size
decreased body weight ( J:112450 )
• reduced at 14 and 21 days of age relative to wild-type mice

digestive/alimentary system
intestinal obstruction ( J:112450 )
• develop intestinal blockage when fed a normal (solid) diet

immune system
lung inflammation ( J:112450 )
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes

Mouse Models of Human Disease
 OMIM IDRef(s)
Cystic Fibrosis; CF 219700 J:112450