Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp2Gt(S20-3G1)Sor mutation
(0 available);
any
Ucp2 mutation
(39 available)
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behavior/neurological
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• after initial i.p. injection of 3.5 mg/kg ethanol, mutants show longer latencies in regaining righting reflex compared to controls
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• mice show a longer latency to resume locomotion after first i.p. injection of ethanol compared to wild-type
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• prior to alcohol treatment on first and fifth days of testing , mutant withdraw from hot plate at similar pace to controls; 4 hours after injection, mutants move away from hot plate more slowly than controls on both the first and fifth test day
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp2Gt(S20-3G1)Sor mutation
(0 available);
any
Ucp2 mutation
(39 available)
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behavior/neurological
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• hyperphagia that normally occurs from ghrelin treatment is severely attenuated in these mice
• food intake was about half that of controls both 1 and 2 hours after ghrelin treatment
• this attenuation in ghrelin-induced food intake still occurred if ghrelin was administered directly into the hypothalamus
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nervous system
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• hypothalamus cells fail to increase their number of mitochondria in response to ghrelin treatment where as in wild-type mitochondrial numbers are significantly increased
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• uncoupled oxygen consumption by hypothalamic mitochondria is increased in wild-type mice treated with ghrelin hormone but not in these mutant mice
• total respiratory capacity of these mitochondria also fail to increase in mice treated with ghrelin hormone compared to wild-type which have about a 50% increase in total respiratory capacity
• the membrane potential of mitochondria fail to be lowered by ghrelin treatment as in controls
• hypothalamic mitochondria significantly increase their production of reactive oxygen species in response to ghrelin-treatment unlike in wild-type mice where increases in ROS production are limited
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Npy-MAPT/Sapphire)1Rck mutation
(1 available)
Ucp2Gt(S20-3G1)Sor mutation
(0 available);
any
Ucp2 mutation
(39 available)
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nervous system
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• ghrelin increases mean action potential frequency of GFP-labeled neuronal perikarya in whole-cell recordings of hypothalamic coronal slices from wild-type mice but not in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pomc-MAPT/Topaz)1Rck mutation
(1 available)
Ucp2Gt(S20-3G1)Sor mutation
(0 available);
any
Ucp2 mutation
(39 available)
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nervous system
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• ghrelin induced recruitment of miniature inhibitory postsynaptic currents
on GFP-labeled cells within the hypothalamus was significantly elevated in wild-type animals but not in these mice
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• grehlin increases the number of symmetric (inhibitory) synapses and decreases the number of asymmetric (excitatory) synapases found in hypothalamus in wild-type but not mutant mice
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Analysis Tools