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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm4(Ikbkb)Rsky
targeted mutation 4, Klaus Rajewsky
MGI:3687199
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
involves: 129P2/OlaHsd * C57BL/6 MGI:3687509
cn2
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * C57BL/6 MGI:3687542
cn3
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sortm4(Ikbkb)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4430555
cn4
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 MGI:5762937
cn5
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
Prdm1tm2Masu/Prdm1tm2Masu
involves: 129P2/OlaHsd * C57BL/6 MGI:5762938
cn6
Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
involves: BALB/c * C57BL/6 * NZB MGI:5296788


Genotype
MGI:3687509
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (36 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal numbers of mature B cells including follicular and marginal zone B cells are produced
• spleens contain well-organized lymphoid architecture with normal follicles and distinct marginal zone




Genotype
MGI:3687542
cn2
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (36 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures
• 1-2 days after crosslinking with BCR, there are more cells is S phase than in wild-type B cell cultures

immune system
• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
• cells on average have a longer lifespan than wild-type B cells
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures

hematopoietic system
• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
• cells on average have a longer lifespan than wild-type B cells
• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures




Genotype
MGI:4430555
cn3
Allelic
Composition
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sortm4(Ikbkb)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Igh-Jtm1Cgn mutation (3 available); any Igh-J mutation (14 available)
Ightm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system
• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice




Genotype
MGI:5762937
cn4
Allelic
Composition
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• enlarged spleens in mice 550-600 days of age

hematopoietic system
• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization
• hyperplasia of B cells in the spleen and bone marrow at 550-600 days
• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days
• clonal or oligoclonal plasma cell expansions
• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens
• enlarged spleens in mice 550-600 days of age

immune system
• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization
• hyperplasia of B cells in the spleen and bone marrow at 550-600 days
• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days
• clonal or oligoclonal plasma cell expansions
• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens
• enlarged spleens in mice 550-600 days of age




Genotype
MGI:5762938
cn5
Allelic
Composition
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+
Prdm1tm2Masu/Prdm1tm2Masu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (15 available)
Prdm1tm2Masu mutation (1 available); any Prdm1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• plasma cell formation is severely impeded 10 days after primary and secondary immunization
• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system
• plasma cell formation is severely impeded 10 days after primary and secondary immunization
• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

mortality/aging
• shortened survival, with 40% survival at around 500 days of age

neoplasm
• mice succumb to a B cell-derived lymphoproliferative disease affecting spleen and lymph nodes, resembling human diffuse large B cell lymphoma
• mice develop clonal lymphomas consistent with activated B cell-diffuse large B cell lymphoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
non-Hodgkin lymphoma DOID:0060060 OMIM:605027
J:167612




Genotype
MGI:5296788
cn6
Allelic
Composition
Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic
Background
involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (20 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cell independent type II antibody responses are restored
• B-1a cell development continues to be defective

hematopoietic system
• B-1a cell development continues to be defective





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory