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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TcraBDC12-4.1)10Jos
transgene insertion 10, Joslin Diabetes Center
MGI:3687036
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687167
cx2
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687163
cx3
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687164
cx4
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687165
cx5
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687166
cx6
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687169


Genotype
MGI:3687167
cx1
Allelic
Composition
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (18 available); any H2 mutation (250 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (23 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (54 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:111874




Genotype
MGI:3687163
cx2
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (27 available); any Rag1 mutation (54 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice are diabetic; diabetes assessed by blood glucose measures >250 mg/dl on two consectutive measurements

endocrine/exocrine glands
• diabetic mice have nearly complete destruction of insulin producing cells
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls

immune system
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes
• mice develop spontaneous diabetes aged 4-32 weeks; diabetes develops only in mice with at least 1 copy of H-2g7 (incidence is 50% with homozygosity, 15% in heterozygotes); both sexes of transgenic mice are equally affected

hematopoietic system
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:111874




Genotype
MGI:3687164
cx3
Allelic
Composition
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (18 available); any H2 mutation (250 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (54 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

immune system
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells
• 15% of mice heterozygous for H2g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2g7 mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:111874




Genotype
MGI:3687165
cx4
Allelic
Composition
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (18 available); any H2 mutation (250 available)
H2q mutation (4 available); any H2 mutation (250 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (54 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:111874




Genotype
MGI:3687166
cx5
Allelic
Composition
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2q mutation (4 available); any H2 mutation (250 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (54 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• O% of mice homozygous for H2q develop diabetes

digestive/alimentary system
N
• mice do not develop insulitis




Genotype
MGI:3687169
cx6
Allelic
Composition
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (18 available); any H2 mutation (250 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

immune system
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected
• transgenic Rag1-sufficient mice do not develop diabetes





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory