• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

• mice are diabetic; diabetes assessed by blood glucose measures >250 mg/dl on two consectutive measurements

• diabetic mice have nearly complete destruction of insulin producing cells

• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes

• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count

• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes

• thymus weight is variable, with some being normal and others having very low weight

• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls

• mice develop spontaneous diabetes aged 4-32 weeks; diabetes develops only in mice with at least 1 copy of H-2^g7 (incidence is 50% with homozygosity, 15% in heterozygotes); both sexes of transgenic mice are equally affected

• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes

• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count

• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes

• thymus weight is variable, with some being normal and others having very low weight

• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls

• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

• 15% of mice heterozygous for H2^g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2^g7 mice

• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

• O% of mice homozygous for H2^q develop diabetes

• mice do not develop insulitis (J:111874)

• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

• transgenic Rag1-sufficient mice do not develop diabetes