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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arid4atm1Alb
targeted mutation 1, Arthur L Beaudet
MGI:3687004
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arid4atm1Alb/Arid4atm1Alb involves: 129S7/SvEvBrd MGI:3817454
hm2
Arid4atm1Alb/Arid4atm1Alb involves: 129S7/SvEvBrd * C57BL/6 MGI:3717484
cx3
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
involves: 129S7/SvEvBrd MGI:3817455
cx4
Arid4atm1Alb/Arid4atm1Alb
Snrpntm4Alb/Snrpn+
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717482
cx5
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4btm1Alb
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717487
cx6
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717488


Genotype
MGI:3817454
hm1
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit increased mortality after 6 months and no mice survives beyond 22 months

reproductive system
• mice exhibit hemorrhage into the ovarian follicles
• female mice mated to wild-type mice exhibit reduced litter size compared to wild-type female mice

hematopoietic system
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice
• increased in the spleen and bone marrow
• after 5 months, mice exhibit extramedullary hematopoiesis in the liver and spleen
• after 5 months, mice exhibit increased erythropoiesis in the spleen
• at 2 to 5 months of age, mice exhibit mild anemia that becomes severe beyond 5 months of age
• in mice older than 5 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleens of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in mice older than 5 months
• at 2 to 5 months of age, mice exhibit a progressive loss of platelets that becomes severe beyond 5 months of age
• at 2 to 5 months of age, mice exhibit mild leukopenia
• at 2 to 5 months of age
• at 2 to 5 months of age
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• beyond 5 months of age
• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the bone marrow and spleen
• after 5 months

endocrine/exocrine glands
• mice exhibit hemorrhage into the ovarian follicles

liver/biliary system
• after 5 months

neoplasm
• mice exhibit chronic myelomonocytic leukemia (CMML) symptoms
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

skeleton
• sick mice exhibit bone marrow with reticulin fibrosis and increased apoptosis compared to wild type mice
• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML) exhibits an increase in T cells and a decreased in erythrocytes and B cells compared to in wild-type mice
• sick mice exhibit bone marrow with reticulin fibrosis

respiratory system
• in mice older than 5 months

cardiovascular system
• mice exhibit hemorrhage into the ovarian follicles

behavior/neurological
• in mice older than 5 months

immune system
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice
• at 2 to 5 months of age, mice exhibit mild leukopenia
• at 2 to 5 months of age
• at 2 to 5 months of age
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• beyond 5 months of age
• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)
• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months
• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)
• after 5 months

integument
• in mice older than 5 months

cellular
• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:141004




Genotype
MGI:3717484
hm2
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• DNA methylation is normal




Genotype
MGI:3817455
cx3
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 25% of mice die before 1 month
• mice exhibit increased mortality at 7 months of age

hematopoietic system
• increased in the spleen and bone marrow
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the peripheral blood of mice with acute myeloid leukemia (AML) contains more than 20% atypical cells with morphology consistent with blasts and immature myeloid precursors unlike in wild-type mice
• the bone marrow of mice with acute myeloid leukemia (AML)
• the spleen of mice of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis and hemophagocytosis
• hematopoietic stem cell populations are expanded in the bone marrow and spleen compared to in wild-type mice and Arid4atm1Alb homozygotes
• in mice with acute myeloid leukemia (AML)

neoplasm
• 83% of mice develop acute myeloid leukemia between 7 and 15 months of age
• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

liver/biliary system
• in mice with acute myeloid leukemia (AML)

skeleton
• mice that exhibit acute myeloid leukemia (AML) also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the bone marrow of mice with AML increase in granulocytes, monocytes, T lymphoid cells, and erythroid cells and a decrease in B lymphoid cells compared to in wild-type mice
• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice and Arid4atm1Alb homozygotes

respiratory system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

cardiovascular system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung, kidney and lymph node blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

renal/urinary system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

growth/size/body
• at 7 weeks of age, mice weigh 30% less than wild-type mice

immune system
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis and hemophagocytosis
• in mice with acute myeloid leukemia (AML)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:141004




Genotype
MGI:3717482
cx4
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Snrpntm4Alb/Snrpn+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
Snrpntm4Alb mutation (0 available); any Snrpn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 7 of 12 mice lack correct DNA methylation patterns




Genotype
MGI:3717487
cx5
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4btm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3717488
cx6
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (37 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 1 of 7 mice lacks correct DNA methylation patterns
• trimethylation at H4K20 is lost in all mice
• maternal imprinting is defective

reproductive system





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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory