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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pycardtm1Flv
targeted mutation 1, Richard A Flavell
MGI:3686870
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pycardtm1Flv/Pycardtm1Flv B6.129S5-Pycardtm1Flv MGI:5085869
hm2
Pycardtm1Flv/Pycardtm1Flv involves: 129S5/SvEvBrd * C57BL/6 MGI:3687250
cn3
Nlrp3tm1Hhf/Nlrp3+
Pycardtm1Flv/Pycardtm1Flv
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 MGI:3850058
cx4
Pycardtm1Flv/Pycardtm1Flv
Slc11a1s/Slc11a1s
B6.129S5-Pycardtm1Flv MGI:3722762


Genotype
MGI:5085869
hm1
Allelic
Composition
Pycardtm1Flv/Pycardtm1Flv
Genetic
Background
B6.129S5-Pycardtm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Flv mutation (0 available); any Pycard mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed or cross-fostered wild-type mice
• mice cross-fostered by wild-type dams exhibit milder colitis than noncross-fostered mice
• however, antibiotic (not oral gancyclovir, amphotericin, or albendazole and praziquantel) treatment restores wild-type levels of susceptibility to DSS-induced colitis
• in untreated mice
• in untreated mice
• in untreated mice

digestive/alimentary system
• colonic crypt hyperplasia in untreated mice
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed or cross-fostered wild-type mice
• mice cross-fostered by wild-type dams exhibit milder colitis than noncross-fostered mice
• however, antibiotic (not oral gancyclovir, amphotericin, or albendazole and praziquantel) treatment restores wild-type levels of susceptibility to DSS-induced colitis

endocrine/exocrine glands
• colonic crypt hyperplasia in untreated mice

hematopoietic system
• in untreated mice
• in untreated mice




Genotype
MGI:3687250
hm2
Allelic
Composition
Pycardtm1Flv/Pycardtm1Flv
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Flv mutation (0 available); any Pycard mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mCMV-treated mice exhibit reduced NK cells in the spleen and IFN-gamma producing splenic NK cells compared with similarly treated wild-type mice
• impaired secretion of IL1A and IL1B in TLR-primed and ATP-treated cells
• significant decrease in serum IL1B levels after challenge with 37.5 mg/kg of LPS
• significant decrease in serum IL18 levels after challenge with 37.5 mg/kg of LPS (J:113333)
• in mCMV-treated mice (J:158969)
• no difference in the degree of ear swelling between sensitized (with trinitrophenylchloride) and naive mice
• impaired secretion of IL1A in TLR-primed and ATP-treated cells
• impaired secretion of IL1B in TLR-primed and ATP-treated cells
• 24 hours after injection of a lethal dose of LPS (37.5 mg/kg) only 15% of mice have died compared to 90% of wild-type mice and maximal mortality (at 7 days) is only 30%
• delayed cell death response in macrophages infected with Salmonella tymphimurium
• mCMV-treated mice exhibit reduced serum IL18 levels, fewer NK cells in the spleen, fewer IFN-gamma-producing splenic NK cells, and increased viral titers compared with similarly treated wild-type mice

homeostasis/metabolism
• significant decrease in serum IL1B levels after challenge with 37.5 mg/kg of LPS
• significant decrease in serum IL18 levels after challenge with 37.5 mg/kg of LPS (J:113333)
• in mCMV-treated mice (J:158969)

hematopoietic system
• mCMV-treated mice exhibit reduced NK cells in the spleen and IFN-gamma producing splenic NK cells compared with similarly treated wild-type mice
• impaired secretion of IL1A and IL1B in TLR-primed and ATP-treated cells




Genotype
MGI:3850058
cn3
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Pycardtm1Flv/Pycardtm1Flv
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (41 available)
Pycardtm1Flv mutation (0 available); any Pycard mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice appear phenotypically normal and do not develop the inflammatory disease that conditional heterozygotes develop on an intact Pycard background




Genotype
MGI:3722762
cx4
Allelic
Composition
Pycardtm1Flv/Pycardtm1Flv
Slc11a1s/Slc11a1s
Genetic
Background
B6.129S5-Pycardtm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Flv mutation (0 available); any Pycard mutation (5 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when infected with Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
• when infected with Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes





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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory