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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gbx2tm1Mrt
targeted mutation 1, Gail R Martin
MGI:3665450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840452
cn2
 		Gbx2tm1Mrt/Gbx2+
Tg(Nes-cre)1Atp/? 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3687492


Genotype
MGI:3840452
cn1
Allelic
Composition		 Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (27 available)
Gbx2tm1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal thalamus morphology ( J:147282 )
• following tamoxifen treatment mild defects in thalamus morphology are seen in some mutants with high levels of recombination but for the most part defects in establishment of dorsal and posterior thalamic boundaries seen in null mice are not seen
• this result and chimera experiments suggest that the function of Gbx2 is cell nonautonomous




Genotype
MGI:3687492
cn2
Allelic
Composition		 Gbx2tm1Mrt/Gbx2+
Tg(Nes-cre)1Atp/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:111945 )
• mice are viable; cre expression is detected in adult brain and kidney (>99% recombination)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory