Analysis Tools
limbs/digits/tail
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• swollen and/or red hindfoot toes; more severe than in heterozygous mice
• swelling results in deformation of the toes, insteps and soles of the hindpaws, including loss of fingertips and necrosis of the hindfeet
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• abnormal bone shape (thin and bent with reduced density) and/or absence of all or part of some phalanges in affected paws
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• Background Sensitivity: penetrance in homozygotes is 100% in a pure C3HeB/FeJ background but reduced on a mixed C3HeB/FeJ and C57BL/6J background
• swollen and/or red hindfoot pads; more severe than in heterozygous mice
• swelling results in deformation of the toes, insteps and soles of the hindpaws, including loss of fingertips and necrosis of the hindfeet
• swelling is also seen in the forepaws
• incidence and severity of swelling increase with age reaching maximal levels by 7 weeks of age
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• thin and bent with reduced density
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• thin and bent with reduced density
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• swelling is also seen in the tail
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immune system
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• inflammation is seen in the joint cavity, periosteum, synovium and bone marrow in the metatarsophalangeal joint region of affected hindpaws
• in the phalanges and metatarsal bones remarkable penetration by inflammatory periosteum and/or endosteum into the epiphysis or diaphysis is seen
• the periosteum is in tight contact with the phalanges and a wavy border between bones is seen
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dermatitis
(
J:112868
)
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• nflammation in the skin is also seen in affected hindpaws, with destruction of the keratinocyte layer and epidermis and fibrin formation
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cardiovascular system
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• bleeding is seen from the skin of affected paws and tails
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skeleton
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• inflammation is seen in the joint cavity, periosteum, synovium and bone marrow in the metatarsophalangeal joint region of affected hindpaws
• in the phalanges and metatarsal bones remarkable penetration by inflammatory periosteum and/or endosteum into the epiphysis or diaphysis is seen
• the periosteum is in tight contact with the phalanges and a wavy border between bones is seen
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• abnormal bone shape (thin and bent with reduced density) and/or absence of all or part of some phalanges in affected paws
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• thin and bent with reduced density
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• thin and bent with reduced density
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• increased size of the bone marrow cavity
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• reduced bone mineral content throughout the entire body
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• reduced bone mineral density throughout the entire body
• bone mineral density is dramatically reduced in trabecular bone, but relatively normal in cortical bone areas
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• reduced cortical bone area in the long bones
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• joints of the phalanxes are more sealed and hard to distinguish in radiographic images
• the periosteum is in tight contact with the phalanges and a wavy border between bones is seen
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integument
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• bleeding is seen from the skin of affected paws and tails
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dermatitis
(
J:112868
)
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• nflammation in the skin is also seen in affected hindpaws, with destruction of the keratinocyte layer and epidermis and fibrin formation
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