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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ace2tm1Cof
targeted mutation 1, Thomas M Coffman
MGI:3665270
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ace2tm1Cof/Ace2tm1Cof involves: 129S6/SvEvTac * C57BL/6 MGI:6437778
ot2
Ace2tm1Cof/Y 129S6/SvEvTac-Ace2tm1Cof MGI:3688532
ot3
Ace2tm1Cof/Y B6.129S6-Ace2tm1Cof MGI:3688531
ot4
Ace2tm1Cof/Y involves: 129S6/SvEvTac * C57BL/6J MGI:3688530


Genotype
MGI:6437778
hm1
Allelic
Composition
Ace2tm1Cof/Ace2tm1Cof
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Cof mutation (0 available); any Ace2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• approximately 70% of adult mice show stromal angiogenesis and corneal neovascularization
• young adult mice show corneal haze, corneal inflammation and vascular remnants and an epithelial defect after central corneal debridement wounding
• approximately 70% of adult mice show corneal inflammatory infiltrate
• in eyes showing haze or cloudiness, the stroma consists of a densely packed mixture of polymorphonuclear, mononuclear, and lymphocytic infiltrates with numerous vascular profiles
• infiltrates include neutrophils, macrophages, T cells and dendritic cells
• young adult mice show increased corneal inflammation after central corneal debridement wounding
• approximately 70% of adult (60-80 weeks of age) mice develop changes in corneal epithelial morphology, ranging from a thin, disorganized epithelium to a more stratified thickened epidermoid tissue
• in severe cased with chronic inflammation, a change from a transparent corneal epithelium to a keratinized, stratified squamous, psoriasiform-like epidermis is seen
• more than 70% of mice develop cloudy corneas in either one or both eyes with age
• young adult mice show corneal haze after central corneal debridement wounding

cardiovascular system
• approximately 70% of adult mice show stromal angiogenesis and corneal neovascularization

homeostasis/metabolism
• young adult mice show corneal haze, corneal inflammation and vascular remnants and an epithelial defect after central corneal debridement wounding

immune system
• approximately 70% of adult mice show corneal inflammatory infiltrate
• in eyes showing haze or cloudiness, the stroma consists of a densely packed mixture of polymorphonuclear, mononuclear, and lymphocytic infiltrates with numerous vascular profiles
• infiltrates include neutrophils, macrophages, T cells and dendritic cells
• young adult mice show increased corneal inflammation after central corneal debridement wounding




Genotype
MGI:3688532
ot2
Allelic
Composition
Ace2tm1Cof/Y
Genetic
Background
129S6/SvEvTac-Ace2tm1Cof
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Cof mutation (0 available); any Ace2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• Background Sensitivity: exhibit normal baseline systolic blood pressure unlike on a mixed or C57BL/6J background
• exhibit enhanced susceptibility to angiotensin-dependent hypertension, as indicated by a 2-fold greater increase in blood pressure following angiotensin II infusion compared to wild-type

homeostasis/metabolism
• after chronic angiotensin II infusion, renal angiotensin II content increases nearly 6-fold compared to wild-type
• after infusion of angiotensin II, serum angiotensin II levels are 3-fold higher than in wild-type




Genotype
MGI:3688531
ot3
Allelic
Composition
Ace2tm1Cof/Y
Genetic
Background
B6.129S6-Ace2tm1Cof
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Cof mutation (0 available); any Ace2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Background Sensitivity: systolic blood pressure is modestly but significantly increased unlike on a coisogenic 129S6/SvEvTac background, however do not develop cardiac hypertrophy




Genotype
MGI:3688530
ot4
Allelic
Composition
Ace2tm1Cof/Y
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Cof mutation (0 available); any Ace2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• modest but significant reduction in heart rate, however, left ventricle end-diastolic and end-systolic dimensions, percentage fractional shortening, and posterior wall thickness were normal
• Background Sensitivity: systolic blood pressure is modestly elevated on the mixed background but not if backcrossed further into 129S6/SvEvTac





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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory