All Phenotypes Ace2<tm1Cof> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace2^tm1Cof/Ace2^tm1Cof	involves: 129S6/SvEvTac * C57BL/6	MGI:6437778
ot2	Ace2^tm1Cof/Y	129S6/SvEvTac-Ace2^tm1Cof	MGI:3688532
ot3	Ace2^tm1Cof/Y	B6.129S6-Ace2^tm1Cof	MGI:3688531
ot4	Ace2^tm1Cof/Y	involves: 129S6/SvEvTac * C57BL/6J	MGI:3688530

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

corneal vascularization ( J:289503 )

• approximately 70% of adult mice show stromal angiogenesis and corneal neovascularization

abnormal corneal wound healing ( J:289503 )

• young adult mice show corneal haze, corneal inflammation and vascular remnants and an epithelial defect after central corneal debridement wounding

increased incidence of corneal inflammation ( J:289503 )

• approximately 70% of adult mice show corneal inflammatory infiltrate

• in eyes showing haze or cloudiness, the stroma consists of a densely packed mixture of polymorphonuclear, mononuclear, and lymphocytic infiltrates with numerous vascular profiles

• infiltrates include neutrophils, macrophages, T cells and dendritic cells

• young adult mice show increased corneal inflammation after central corneal debridement wounding

abnormal corneal epithelium morphology ( J:289503 )

• approximately 70% of adult (60-80 weeks of age) mice develop changes in corneal epithelial morphology, ranging from a thin, disorganized epithelium to a more stratified thickened epidermoid tissue

• in severe cased with chronic inflammation, a change from a transparent corneal epithelium to a keratinized, stratified squamous, psoriasiform-like epidermis is seen

corneal opacity ( J:289503 )

• more than 70% of mice develop cloudy corneas in either one or both eyes with age

• young adult mice show corneal haze after central corneal debridement wounding

cardiovascular system

corneal vascularization ( J:289503 )

• approximately 70% of adult mice show stromal angiogenesis and corneal neovascularization

homeostasis/metabolism

abnormal corneal wound healing ( J:289503 )

• young adult mice show corneal haze, corneal inflammation and vascular remnants and an epithelial defect after central corneal debridement wounding

immune system

increased incidence of corneal inflammation ( J:289503 )

• approximately 70% of adult mice show corneal inflammatory infiltrate

• in eyes showing haze or cloudiness, the stroma consists of a densely packed mixture of polymorphonuclear, mononuclear, and lymphocytic infiltrates with numerous vascular profiles

• infiltrates include neutrophils, macrophages, T cells and dendritic cells

• young adult mice show increased corneal inflammation after central corneal debridement wounding

Allelic Composition	Ace2^tm1Cof/Y
Genetic Background	129S6/SvEvTac-Ace2^tm1Cof

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2^tm1Cof mutation (0 available); any Ace2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:113108 )

N	• Background Sensitivity: exhibit normal baseline systolic blood pressure unlike on a mixed or C57BL/6J background

hypertension ( J:113108 )

• exhibit enhanced susceptibility to angiotensin-dependent hypertension, as indicated by a 2-fold greater increase in blood pressure following angiotensin II infusion compared to wild-type

homeostasis/metabolism

increased angiotensin II level ( J:113108 )

• after chronic angiotensin II infusion, renal angiotensin II content increases nearly 6-fold compared to wild-type

increased circulating angiotensin II level ( J:113108 )

• after infusion of angiotensin II, serum angiotensin II levels are 3-fold higher than in wild-type

Allelic Composition	Ace2^tm1Cof/Y
Genetic Background	B6.129S6-Ace2^tm1Cof

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2^tm1Cof mutation (0 available); any Ace2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:113108 )

• Background Sensitivity: systolic blood pressure is modestly but significantly increased unlike on a coisogenic 129S6/SvEvTac background, however do not develop cardiac hypertrophy

Allelic Composition	Ace2^tm1Cof/Y
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2^tm1Cof mutation (0 available); any Ace2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased heart rate ( J:113108 )

• modest but significant reduction in heart rate, however, left ventricle end-diastolic and end-systolic dimensions, percentage fractional shortening, and posterior wall thickness were normal

increased systemic arterial systolic blood pressure ( J:113108 )

• Background Sensitivity: systolic blood pressure is modestly elevated on the mixed background but not if backcrossed further into 129S6/SvEvTac

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