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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aldh1a2tm2Soc
targeted mutation 2, Shanthini Sockanathan
MGI:3665181
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Aldh1a2tm1Soc/Aldh1a2tm2Soc Not Specified MGI:3665267
cn2
 		Aldh1a2tm1Soc/Aldh1a2tm2Soc
Isl1tm1(cre)Tmj/Isl1+ 		involves: 129X1/SvJ MGI:3665269
cn3
 		Aldh1a2tm1Soc/Aldh1a2tm2Soc
Tg(Dll1-cre)1Gos/0 		Not Specified MGI:3665268


Genotype
MGI:3665267
ht1
Allelic
Composition		 Aldh1a2tm1Soc/Aldh1a2tm2Soc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2tm1Soc mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm2Soc mutation (0 available); any Aldh1a2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:112635 )
• viable and fertile with no gross abnormalities




Genotype
MGI:3665269
cn2
Allelic
Composition		 Aldh1a2tm1Soc/Aldh1a2tm2Soc
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2tm1Soc mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm2Soc mutation (0 available); any Aldh1a2 mutation (36 available)
Isl1tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron innervation pattern ( J:112635 )
• at E13.5 both ventral and dorsal projecting lateral motor column neurons appear stunted or atrophied and in some cases are retracted
decreased motor neuron number ( J:112635 )
• at E13.5 at the forelimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 30% and 25%, respectively; however no difference in the number of lateral motor column lateral motor neurons is detected at E12.5
• at E13.5 at the hindlimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 17% and 20%, respectively




Genotype
MGI:3665268
cn3
Allelic
Composition		 Aldh1a2tm1Soc/Aldh1a2tm2Soc
Tg(Dll1-cre)1Gos/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2tm1Soc mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm2Soc mutation (0 available); any Aldh1a2 mutation (36 available)
Tg(Dll1-cre)1Gos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron innervation pattern ( J:112635 )
• at E12.5 at the forelimb level, stunting of the fine branches of dorsally projecting neurons of the radial and ulnar nerves is seen; however ventral projections appear unaffected
decreased motor neuron number ( J:112635 )
• about a 10% and 20% reduction in total motor neuron numbers and lateral motor column lateral motor neurons, respectively, are seen at E12.5 at the forelimb level, but no increase in cell death is detected
• at the hindlimb level at E12.5 a 14% decrease in lateral motor column lateral motor neurons is seen

homeostasis/metabolism
abnormal vitamin A level ( J:112635 )
• 50% reduction in retinoic acid levels in tissue homogenates from the forelimb region

limbs/digits/tail
limbs/digits/tail phenotype ( J:112635 )
N
• digit morphology and flexure of the distal limbs are similar to controls in adults




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory