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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(CTNNB1)Nerl
targeted mutation 1 Claus Nerlov
MGI:3664628
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
involves: 129P2/OlaHsd * BALB/c MGI:3706810
cn2
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3706809


Genotype
MGI:3706810
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm1(CTNNB1)Nerl mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• induction of recombination in pre-B cells does not produce an altered phenotype




Genotype
MGI:3706809
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CTNNB1)Nerl mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• wheni injected with poly(I:C) to induce cre expression, mutants become moribund and die within 2-3 weeks

immune system
• after cre induction, mutants have ~25% of control cell numbers in thymus
• a block at the DN1-DN2 transition is found
• myeloid cells are almost totally absent in induced mutants
• induced mutants have fewer leukocytes
• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells
• after cre induction, mice show a loss of granulocytic cells

hematopoietic system
• after cre induction, mutants have ~25% of control cell numbers in thymus
• a block at the DN1-DN2 transition is found
• myeloid cells are almost totally absent in induced mutants
• after cre induction, mice develop severe anemia
• after cre induction, mutants have ~25% of control bone marrow cell numbers
• bone marrow shows abnormal presence of immature erythroid cells in induced mutants
• peripheral blood from induced mutants is pale and has reduced red blood cell counts
• hemoglobin concentration in peripheral blood of induced mutants is reduced
• platelet count in induced mutants is reduced
• induced mutants have fewer leukocytes
• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells
• after cre induction, mice show a loss of granulocytic cells

endocrine/exocrine glands
• after cre induction, mutants have ~25% of control cell numbers in thymus





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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory